Fedovapagon

• 常用名: Fedovapagon
• 英文名: Fedovapagon
• CAS号: 347887-36-9
• 分子量: 462.58400
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₇H₃₄N₄O₃
• 熔点: N/A
• 闪点: N/A

Fedovapagon用途

Fedovapagon 是一种选择性的加压素 V2R 激动剂,EC50 值为 24 nM。被开发用于夜尿症。

Fedovapagon名称

• 英文名: (2S)-2-N,2-N-dimethyl-1-N-[[2-methyl-4-(2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]methyl]pyrrolidine-1,2-dicarboxamide

Fedovapagon生物活性

• 描述: Fedovapagon 是一种选择性的加压素 V2R 激动剂,EC50 值为 24 nM。被开发用于夜尿症。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 靶点实验:

  EC50：24 nM (V2R)[1]

• 参考文献:

  [1]. Yea CM, et al. New benzylureas as a novel series of potent, nonpeptidic vasopressin V2 receptor agonists. J Med Chem. 2008 Dec 25;51(24):8124-34.

Fedovapagon物理化学性质

• 分子式: C₂₇H₃₄N₄O₃
• 分子量: 462.58400
• 精确质量: 462.26300
• PSA: 76.45000
• LogP: 3.94760
• InChIKey: RUOLFWZIFNQQGH-DEOSSOPVSA-N
• SMILES: Cc1cc(C(=O)N2CCCCc3ccccc32)ccc1CNC(=O)N1CCCC1C(=O)N(C)C
• 储存条件: 2-8°C，惰性气体

Fedovapagon靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：NCATS Human Liver Microsomal (HLM) Stability Profiling 来源：NCGC 靶标：N/A External Id：ADME-HLM1

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase... 来源：NCGC External Id：GPx1-biochemical-p4-p7

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Fedovapagon英文别名

• 1-(2-methyl-4-(2,3,4,5-tetrahydro-1-benzazepin-1-ylcarbonyl)benzylcarbamoyl)-L-proline-N,N-dimethylamide
• UNII-VX2GBO4I0V
• Fedovapagon
• Fedovapagon [INN]
• (2S)-N2,N2-dimethyl-N1-((2-Methyl-4-(2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)phenyl)methyl)pyrrolidine-1,2-dicarboxamide
• (2S)-N(sup 2),N(sup 2)-Dimethyl-N(sup 1)-((2-methyl-4-(2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl)phenyl)methyl)pyrrolidine-1,2-dicarboxamide