3,4-二氢-3-氧代-4-BETA-D-呋喃核糖基-2-吡嗪甲酰胺

• 常用名: 3,4-二氢-3-氧代-4-BETA-D-呋喃核糖基-2-吡嗪甲酰胺
• 英文名: 3-Oxo-4-(?D-ribofuranosyl)-3,4-dihydro-2-pyrazinecarboxamide
• CAS号: 356782-84-8
• 分子量: 271.23
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₀H₁₃N₃O₆
• 熔点: N/A
• 闪点: N/A

用途

3,4-二氢-3-氧代-4-β-D-呋喃核糖基-2-吡嗪甲酰胺是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

名称

• 中文名: 3,4-二氢-3-氧代-4-BETA-D-呋喃核糖基-2-吡嗪甲酰胺
• 英文名: 3,4-dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxaMide

生物活性

• 描述: 3,4-二氢-3-氧代-4-β-D-呋喃核糖基-2-吡嗪甲酰胺是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

物理化学性质

• 分子式: C₁₀H₁₃N₃O₆
• 分子量: 271.23
• InChIKey: XVXWUBIIHFDOJO-KQYNXXCUSA-N
• SMILES: NC(=O)c1nccn(C2OC(CO)C(O)C2O)c1=O
• 外观性状: 类白色固体
• 储存条件: 室温

靶点实验

查看更多实验

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Antiviral activity against YFV infected in african green monkey Vero cells assessed a... 来源：ChEMBL 靶标：Yellow fever virus External Id：CHEMBL921320

实验名称：Antiviral activity against YFV infected in african green monkey CV1 cells assessed as... 来源：ChEMBL 靶标：Yellow fever virus External Id：CHEMBL921321

实验名称：Selectivity index, ratio of CC50 for African green monkey vero cells to EC90 for Yell... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1637502

实验名称：Toxicity in YFV infected Syrian golden hamster assessed as assessed as weight change ... 来源：ChEMBL 靶标：Mesocricetus auratus External Id：CHEMBL921328

实验名称：Toxicity in YFV infected Syrian golden hamster assessed as assessed as weight change ... 来源：ChEMBL 靶标：Mesocricetus auratus External Id：CHEMBL921327

实验名称：Antiviral activity against YFV Jimenez infected in Syrian golden hamster assessed as ... 来源：ChEMBL 靶标：Yellow fever virus External Id：CHEMBL922299

实验名称：Antiviral activity against YFV Jimenez infected in Syrian golden hamster assessed as ... 来源：ChEMBL 靶标：Yellow fever virus External Id：CHEMBL922300

共82条，当前第1页，共9页

1

2

3

4

5