(1S,2R,4aS,6aS,6aS,6bR,8aS,10S,12aS,14bR)-10-acetyloxy-1,2,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,5,6,6a,7,8,8a,10,11,12,14b-tetradecahydropicene-4a-carboxylic acid

• 常用名: (1S,2R,4aS,6aS,6aS,6bR,8aS,10S,12aS,14bR)-10-acetyloxy-1,2,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,5,6,6a,7,8,8a,10,11,12,14b-tetradecahydropicene-4a-carboxylic acid
• 英文名: (1S,2R,4aS,6aS,6aS,6bR,8aS,10S,12aS,14bR)-10-acetyloxy-1,2,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,5,6,6a,7,8,8a,10,11,12,14b-tetradecahydropicene-4a-carboxylic acid
• CAS号: 35959-01-4
• 分子量: 512.72
• 密度: 1.13g/cm3
• 沸点: 601.1ºC at 760 mmHg
• 分子式: C₃₂H₄₈O₅
• 熔点: N/A
• 闪点: 184.7ºC

用途

3-Acetyl-11-keto-ursolic acid (Compound 18) 是一种来源于 Eriobotrya japonica 叶片的三萜化合物。3-Acetyl-11-keto-ursolic acid 具有 11b-羟基类固醇脱氢酶1 (11b-HSD1) 抑制活性。3-Acetyl-11-keto-ursolic acid 可用于抗糖尿病的研究。

名称

• 英文名: 1,4-dichloro-2-fluorobenzene

生物活性

• 描述: 3-Acetyl-11-keto-ursolic acid (Compound 18) 是一种来源于 Eriobotrya japonica 叶片的三萜化合物。3-Acetyl-11-keto-ursolic acid 具有 11b-羟基类固醇脱氢酶1 (11b-HSD1) 抑制活性。3-Acetyl-11-keto-ursolic acid 可用于抗糖尿病的研究。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Rollinger JM, et al. 11beta-Hydroxysteroid dehydrogenase 1 inhibiting constituents from Eriobotrya japonica revealed by bioactivity-guided isolation and computational approaches. Bioorg Med Chem. 2010 Feb 15;18(4):1507-15.

物理化学性质

• 密度: 1.13g/cm3
• 沸点: 601.1ºC at 760 mmHg
• 分子式: C₃₂H₄₈O₅
• 分子量: 512.72
• 闪点: 184.7ºC
• 精确质量: 512.35000
• PSA: 80.67000
• LogP: 6.83930
• InChIKey: XDHCWTUZCOFKRH-CIKBGXLUSA-N
• SMILES: CC(=O)OC1CCC2(C)C(CCC3(C)C2C(=O)C=C2C4C(C)C(C)CCC4(C(=O)O)CCC23C)C1(C)C
• 折射率: 1.549

英文别名

• 3-acetyl-11-keto-ursolic acid
• 3-O-Acetyl-1,2-O-isopropylidene-|A-D-glucofuranose
• 11-oxo-3O-acetylursolic acid
• 11-oxo-ursolic acid acetate
• 3-O-acetyl-11-oxoursolic acid
• 11-oxo acetyl ursolic acid