L-亮氨酸-D2

• 常用名: L-亮氨酸-D2
• 英文名: L-(3,3-2H2)Leucine
• CAS号: 362049-59-0
• 分子量: 133.185
• 密度: 1.0±0.1 g/cm3
• 沸点: 225.8±23.0 °C at 760 mmHg
• 分子式: C₆H₁₁D₂NO₂
• 熔点: N/A
• 闪点: 90.3±22.6 °C

L-亮氨酸-D2用途

L-亮氨酸-d2是氘标记的L-亮氨酸。L-亮氨酸是一种必需的支链氨基酸(BCAA),可激活mTOR信号通路[1]。

L-亮氨酸-D2名称

本表展示该化学物质的中文名称、英文系统名、各类中文与英文别名信息。

• 中文名: L-亮氨酸-D2
• 英文名: l-leucine-3,3-d2

L-亮氨酸-D2生物活性

本表记录该化合物相关生物活性、作用靶点、活性说明与生物实验相关数据。

• 描述: L-亮氨酸-d2是氘标记的L-亮氨酸。L-亮氨酸是一种必需的支链氨基酸(BCAA),可激活mTOR信号通路[1]。
• 相关类别:
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> mTOR
  研究领域 >> 代谢疾病
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [2]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

  [3]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

  [4]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

  [5]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

  [6]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

  [7]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

  [8]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

  [9]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

  [10]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.

  [11]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

  [12]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

  [13]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

  [14]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

  [15]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

  [16]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

  [17]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

  [18]. Baoshan Xu, et al. Stimulation of mTORC1 with L-leucine rescues defects associated with Roberts syndrome. PLoS Genet. 2013;9(10):e1003857.

  [19]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

  [20]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

  [21]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

  [22]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

  [23]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

  [24]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

  [25]. Bruckbauer A, et al. Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice. Nutr Metab (Lond). 2012 Aug 22;9(1):77.

L-亮氨酸-D2物理化学性质

本表包含该物质理化参数，如熔点、沸点、密度、溶解度、旋光性等理化指标，无数据项标记为N/A。

• 密度: 1.0±0.1 g/cm3
• 沸点: 225.8±23.0 °C at 760 mmHg
• 分子式: C₆H₁₁D₂NO₂
• 分子量: 133.185
• 闪点: 90.3±22.6 °C
• 精确质量: 133.107178
• PSA: 63.32000
• LogP: 0.73
• 蒸汽压: 0.0±0.9 mmHg at 25°C
• 折射率: 1.463

L-亮氨酸-D2英文别名

本表罗列该化合物全部英文别名、系统命名、CAS别名等英文名称集合。

• L-Leucine-3,3-d
• L-(3,3-H)Leucine

L-亮氨酸-D2常见问题

本部分为该化合物相关常见问答，包含基础参数、性状、储存条件等高频咨询问题与对应答案。

Q: 362049-59-0的中文名称是什么？

A: 362049-59-0的中文名称为L-亮氨酸-D2。

Q: L-亮氨酸-D2的分子式是什么？

A: L-亮氨酸-D2分子式为C6H11D2NO2。

Q: L-亮氨酸-D2有哪些英文别名？

A: L-亮氨酸-D2英文别名有：L-Leucine-3,3-d、L-(3,3-H)Leucine。

Q: L-亮氨酸-D2的CAS号是多少？

A: L-亮氨酸-D2CAS号为362049-59-0。

Q: L-亮氨酸-D2的LogP（油水分配系数）是多少？

A: L-亮氨酸-D2LogP（油水分配系数）为0.73。

Q: L-亮氨酸-D2有什么用途？

A: L-亮氨酸-D2主要用途：L-亮氨酸-d2是氘标记的L-亮氨酸。L-亮氨酸是一种必需的支链氨基酸(BCAA),可激活mTOR信号通路[1]。

Q: L-亮氨酸-D2的英文名称是什么？

A: L-亮氨酸-D2英文名称为l-leucine-3,3-d2。

Q: L-亮氨酸-D2的分子量是多少？

A: L-亮氨酸-D2分子量为133.185。

Q: L-亮氨酸-D2的沸点是多少？

A: L-亮氨酸-D2沸点为225.8±23.0 °C at 760 mmHg。

Q: L-亮氨酸-D2的极性表面积PSA是多少？

A: L-亮氨酸-D2极性表面积PSA为63.32000。

L-亮氨酸-D2生产厂家

本表列出该化合物相关生产厂商、供应商信息，包含厂家名称、产品供应相关参考信息。

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