3'-去磷酸辅酶 A

更新时间：2025-08-25 17:17:12

3'-去磷酸辅酶 A结构式	常用名	3'-去磷酸辅酶 A	英文名	3'-O-dephosphono-coenzyme A
	CAS号	3633-59-8	分子量	687.55400
	密度	1.85±0.1 g/cm3(Predicted)	沸点	N/A
	分子式	C₂₁H₃₅N₇O₁₃P₂S	熔点	N/A
	MSDS	美版	闪点	N/A

3'-去磷酸辅酶 A用途

去磷酸辅酶A是辅酶A(CoA)的直接前体。去磷酸辅酶A激酶(DPCK)催化去磷酸辅酶CoA的ATP依赖性磷酸化,这是辅酶A(CoA)生物合成的最后一步[1][2]。

中文名	3′-脱磷酸辅酶A
英文名	3'-dephospho-CoA
英文别名	更多

描述	去磷酸辅酶A是辅酶A(CoA)的直接前体。去磷酸辅酶A激酶(DPCK)催化去磷酸辅酶CoA的ATP依赖性磷酸化,这是辅酶A(CoA)生物合成的最后一步[1][2]。
相关类别	研究领域 >> 其他
靶点实验	Human Endogenous Metabolite
参考文献	[1]. Swift RP, et al. Dephospho-CoA kinase, a nuclear-encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption. EMBO J. 2021 Aug 16;40(16):e107247. [2]. Shimosaka T, et al. Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea. mBio. 2019 Jul 23;10(4):e01146-19.

密度	1.85±0.1 g/cm3(Predicted)
分子式	C₂₁H₃₅N₇O₁₃P₂S
分子量	687.55400
精确质量	687.14900
PSA	358.45000
InChIKey	KDTSHFARGAKYJN-IBOSZNHHSA-N
SMILES	CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(n2cnc3c(N)ncnc32)C(O)C1O)C(O)C(=O)NCCC(=O)NCCS
储存条件	-20 °C，密封，干燥

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

Simultaneous high-performance liquid chromatography determination of coenzyme A, dephospho-coenzyme A, and acetyl-coenzyme A in normal and pantothenic acid-deficient rats.

Anal. Biochem. 430(2) , 151-5, (2012)

We describe here a simultaneous high-performance liquid chromatography method for practical and rapid determination of coenzyme A (CoA), dephospho-CoA, and acetyl-CoA in tissues. These coenzymes are b...

Identification of the active site of phosphoribosyl-dephospho-coenzyme A transferase and relationship of the enzyme to an ancient class of nucleotidyltransferases.

Biochemistry 39(43) , 13233-40, (2000)

Malonate decarboxylase from Klebsiella pneumoniae contains an acyl carrier protein (MdcC) to which a 2'-(5' '-phosphoribosyl)-3'-dephospho-CoA prosthetic group is attached via phosphodiester linkage t...

Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli.

J. Biol. Chem. 274(38) , 27105-11, (1999)

Phosphopantetheine adenylyltransferase (PPAT) catalyzes the penultimate step in coenzyme A (CoA) biosynthesis: the reversible adenylation of 4'-phosphopantetheine yielding 3'-dephospho-CoA and pyropho...

3′-Dephosphocoenzyme A

3'-DEPHOSPHOCOENZYME A