ZQ-16

• 常用名: ZQ-16
• 英文名: ZQ 16
• CAS号: 376616-73-8
• 分子量: 228.311
• 密度: 1.3±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₀H₁₆N₂O₂S
• 熔点: N/A
• 闪点: N/A

ZQ-16用途

一种新的GPR84强效和选择性激动剂,诱导钙反应,EC50为0.213 uM；在表达其他FFA的HEK293细胞中不会引起钙反应,包括GPR40,GPR41,GPR119和GPR120；HEK293中细胞内钙浓度增加/Gα16/GPR84细胞,EC50为1.01 uM；激活几种GPR84介导的细胞信号通路,包括钙动员,抑制cAMP积累,ERK1/2磷酸化,受体脱敏和内化,以及受体-β-抑制蛋白相互作用；减少毛喉素刺激的HEK293细胞中cAMP积累,EC50为0.134 uM。

ZQ-16名称

• 英文名: ZQ-16

ZQ-16生物活性

• 描述: 一种新的GPR84强效和选择性激动剂,诱导钙反应,EC50为0.213 uM；在表达其他FFA的HEK293细胞中不会引起钙反应,包括GPR40,GPR41,GPR119和GPR120；HEK293中细胞内钙浓度增加/Gα16/GPR84细胞,EC50为1.01 uM；激活几种GPR84介导的细胞信号通路,包括钙动员,抑制cAMP积累,ERK1/2磷酸化,受体脱敏和内化,以及受体-β-抑制蛋白相互作用；减少毛喉素刺激的HEK293细胞中cAMP积累,EC50为0.134 uM。
• 参考文献: References 1. Zhang Q, et al. J Pharmacol Exp Ther. 2016 May;357(2):337-44. 2. Liu Y, et al. ACS Med Chem Lett. 2016 Mar 30;7(6):579-83. View Related Products by Target Free Fatty Acid Receptor (FFAR)

ZQ-16物理化学性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₁₀H₁₆N₂O₂S
• 分子量: 228.311
• 精确质量: 228.093246
• LogP: 2.68
• InChIKey: UYXOAKRMLQKLQX-UHFFFAOYSA-N
• SMILES: CCCCCCSc1nc(O)cc(=O)[nH]1
• 折射率: 1.588

ZQ-16靶点实验

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实验名称：Potency index, ratio of 6-OAU EC50 to compound EC50 for GPR84 (unknown origin) expres... 来源：ChEMBL 靶标：G-protein coupled receptor 84 External Id：CHEMBL3830329

实验名称：Agonist activity at GPR84 (unknown origin) expressed in in HEK293 cells assessed as i... 来源：ChEMBL 靶标：G-protein coupled receptor 84 External Id：CHEMBL3830330

实验名称：Agonist activity at mouse GPR84 assessed as forskolin induced cAMP production incubat... 来源：ChEMBL 靶标：G-protein coupled receptor 83 External Id：CHEMBL5531191

实验名称：Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Gal... 来源：ChEMBL 靶标：G-protein coupled receptor 84 External Id：CHEMBL3830327

实验名称：Agonist activity at GPR84 (unknown origin) expressed in HEK293 cells coexpressing Gal... 来源：ChEMBL 靶标：G-protein coupled receptor 84 External Id：CHEMBL3830328

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：Selectivity ratio of EC50 for agonist activity at recombinant human GPR84 expressed i... 来源：ChEMBL 靶标：G-protein coupled receptor 84 External Id：CHEMBL4343784

实验名称：Selectivity ratio of EC50 for agonist activity at recombinant human GPR84 expressed i... 来源：ChEMBL 靶标：G-protein coupled receptor 84 External Id：CHEMBL4343783

实验名称：Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of be... 来源：ChEMBL 靶标：G-protein coupled receptor 84 External Id：CHEMBL4712172

实验名称：Displacement of [3H]140 from GPR84 (unknown origin) expressed in Flp-In-T-REx-293 cel... 来源：ChEMBL 靶标：G-protein coupled receptor 84 External Id：CHEMBL5531175

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ZQ-16英文别名

• 2-(Hexylsulfanyl)-6-hydroxy-4(3H)-pyrimidinone
• 2-(Hexylsulfanyl)-6-hydroxypyrimidin-4(3H)-one
• ZQ-16
• MFCD00475645
• 2-(hexylthio)-6-hydroxy-4(3H)-pyrimidinone