AA147

• 常用名: AA147
• 英文名: AA 147
• CAS号: 393121-74-9
• 分子量: 255.31
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₆H₁₇NO₂
• 熔点: N/A
• 闪点: N/A

AA147用途

AA147 是一种小分子内质网 (ER) 蛋白稳态调节剂,选择性激活未折叠蛋白反应 (UPR) 的 ATF6 臂,详细信息请参考专利文献 WO2017117430A1 中的化合物 147*。

AA147名称

• 中文名: N-(2-羟基-5-甲基苯基)-3-苯基丙酰胺
• 英文名: AA147

AA147生物活性

• 描述: AA147 是一种小分子内质网 (ER) 蛋白稳态调节剂,选择性激活未折叠蛋白反应 (UPR) 的 ATF6 臂,详细信息请参考专利文献 WO2017117430A1 中的化合物 147*。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 靶点实验:

  ATF6[1]

• 参考文献:

  [1]. Christina COOLEY, et al. Regulators of the endoplasmic reticulum proteostasis network. WO2017117430A1.

AA147物理化学性质

• 分子式: C₁₆H₁₇NO₂
• 分子量: 255.31
• InChIKey: AWHLTHOHBAGPMY-UHFFFAOYSA-N
• SMILES: Cc1ccc(O)c(NC(=O)CCc2ccccc2)c1
• 储存条件: 2-8°C， 干燥

AA147靶点实验

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实验名称：qHTS screening for TAG (triacylglycerol) accumulators in algae 来源：11812 靶标：N/A External Id：FATTTLab-Algae-Lipid

实验名称：Drug metabolism assessed as intact compound incubated for 24 hrs in presence of NADP+... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4344947

实验名称：Drug metabolism assessed as recombinant CYP1A2 (unknown origin)-mediated oxidation in... 来源：ChEMBL 靶标：Cytochrome P450 1A2 External Id：CHEMBL4344946

实验名称：Alphascreen assay for small molecules abrogating mHTT-CaM Interaction 来源：24983 靶标：Huntingtin External Id：KUHTS-Muma KU-CaM-Htt INH-01

实验名称：Activation of ATF6 in simulated-ischemia-reperfusion NRVM isolated from Sprague-Dawle... 来源：ChEMBL 靶标：Cyclic AMP-dependent transcription factor ATF-6 alpha External Id：CHEMBL4344954

实验名称：Activation of ATF6 in simulated-ischemia-reperfusion NRVM isolated from Sprague-Dawle... 来源：ChEMBL 靶标：Cyclic AMP-dependent transcription factor ATF-6 alpha External Id：CHEMBL4344953

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Cytoprotection against hydrogen peroxide-induced toxicity in NRVM isolated from Sprag... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4344952

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