15-KETO-曲伏前列素

• 常用名: 15-KETO-曲伏前列素
• 英文名: 15-Keto Travoprost
• CAS号: 404830-45-1
• 分子量: 498.532
• 密度: 1.2±0.1 g/cm3
• 沸点: 577.5±50.0 °C at 760 mmHg
• 分子式: C₂₆H₃₃F₃O₆
• 熔点: N/A
• 闪点: 303.1±30.1 °C

15-KETO-曲伏前列素用途

15酮曲伏前列素(15酮氟前列醇异丙酯)是曲伏前列腺素(HY-B0584)的代谢物。15酮曲伏前列素对睫毛的生长和增厚有刺激作用[1][2]。

15-KETO-曲伏前列素名称

• 中文名: 15-KETO-曲伏前列素
• 英文名: propan-2-yl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]but-1-enyl]cyclopentyl]hept-5-enoate

15-KETO-曲伏前列素生物活性

• 描述: 15酮曲伏前列素(15酮氟前列醇异丙酯)是曲伏前列腺素(HY-B0584)的代谢物。15酮曲伏前列素对睫毛的生长和增厚有刺激作用[1][2]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体外研究: 15 Keto Travoprost(80µgr/mL)可用于治疗特发性睫毛少毛症[1]。
• 参考文献:

  [1]. Fabbrocini G, et al. 15 keto fluprostenol isopropyl ester (80 µgr/mL) gel for cosmetic eyelash growth and enhancement. J Cosmet Dermatol. 2019 Apr;18(2):545-549.

  [2]. Ciro C, et al. Effect of Fluprostenol Isopropyl Ester and 15-Keto Fluprostenol on Eyelash Growth: A Clinical and Pharmacologic Study. Skinmed. 2018 Jul 1;16(4):231-233.

15-KETO-曲伏前列素物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 577.5±50.0 °C at 760 mmHg
• 分子式: C₂₆H₃₃F₃O₆
• 分子量: 498.532
• 闪点: 303.1±30.1 °C
• 精确质量: 498.222931
• PSA: 93.06000
• LogP: 3.82
• InChIKey: KSDDYCRRTVADFZ-OHDKTVHDSA-N
• SMILES: CC(C)OC(=O)CCCC=CCC1C(O)CC(O)C1C=CC(=O)COc1cccc(C(F)(F)F)c1
• 蒸汽压: 0.0±1.7 mmHg at 25°C
• 折射率: 1.541

15-KETO-曲伏前列素靶点实验

查看更多实验

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：Discovering small molecule activators of G protein-gated inwardly-rectifying potassiu... 来源：15621 靶标：G protein-activated inward rectifier potassium channel 2 External Id：VANDERBILT_HTS_GIRK2_MPD

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15-KETO-曲伏前列素英文别名

• Travoprost impurity,15-keto derivative-[USP]
• UNII-4U2P9U9Z66
• Isopropyl (5Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl}cyclopentyl]-5-heptenoate
• 15-Oxo travoprost
• 15-keto Fluprostenol isopropyl ester
• 15-Keto Travoprost
• (5Z)-7-[(1R,2R,3R,5S)-3,5-Dihydroxy-2-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic Acid 1-Methylethyl Ester
• (5Z,13E)-(9S,11R)-9,11,-Dihydroxy-15-oxo-16-(m-trifluoromethylphenoxy)-17,18,19,20-tetranor-5,13-prostadienoic acid,isopropyl ester