SW-083688

• 常用名: SW-083688
• 英文名: SW-083688
• CAS号: 422281-45-6
• 分子量: 455.529
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₂₅N₃O₅S
• 熔点: N/A
• 闪点: N/A

SW-083688用途

SW-083688(SW083688)是一种有效的,高选择性的TAOK2(千和一激酶2,MAP3K17)抑制剂,IC50为1.3 uM；增加p62的丰度并抑制自噬；TAOK2是p38 MAP激酶级联的激活剂,上调响应环境压力,和潜在的癌症治疗目标。

SW-083688名称

• 英文名: SW-083688

SW-083688生物活性

• 描述: SW-083688(SW083688)是一种有效的,高选择性的TAOK2(千和一激酶2,MAP3K17)抑制剂,IC50为1.3 uM；增加p62的丰度并抑制自噬；TAOK2是p38 MAP激酶级联的激活剂,上调响应环境压力,和潜在的癌症治疗目标。
• 参考文献: References 1. Piala AT, et al. Bioorg Med Chem Lett. 2016 Aug 15;26(16):3923-7. View Related Products by Target MEKK (MAP3K)

SW-083688物理化学性质

• 分子式: C₂₃H₂₅N₃O₅S
• 分子量: 455.529
• InChIKey: CMHKKTGCFWZUEZ-UHFFFAOYSA-N
• SMILES: CCOCCCn1c(=S)[nH]c2cc(C(=O)NCC3COc4ccccc4O3)ccc2c1=O
• 储存条件: 2-8°C，密封，干燥

SW-083688靶点实验

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实验名称：Inhibition of human TAO2 来源：ChEMBL 靶标：Serine/threonine-protein kinase TAO2 External Id：CHEMBL4479307

实验名称：Inhibition of TAOK2 in human U2OS cells assessed as inhibition of cellular autophagy ... 来源：ChEMBL 靶标：Serine/threonine-protein kinase TAO2 External Id：CHEMBL4479294

实验名称：Inhibition of TAOK2 in human U2OS cells assessed as inhibition of cellular autophagy ... 来源：ChEMBL 靶标：Serine/threonine-protein kinase TAO2 External Id：CHEMBL4479295

实验名称：Inhibition of rat TAOK2 (1 to 320 residues) expressed in Baculovirus/insect cell expr... 来源：ChEMBL 靶标：Serine/threonine-protein kinase TAO2 External Id：CHEMBL4479297

实验名称：Binding affinity to p38 (unknown origin) assessed as change in melting temperature at... 来源：ChEMBL 靶标：Mitogen-activated protein kinase 11 External Id：CHEMBL4479298

实验名称：Binding affinity to ASK1 (unknown origin) assessed as change in melting temperature a... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL4479299

实验名称：Binding affinity to rat TAOK2 (1 to 320 residues) expressed in Baculovirus/insect cel... 来源：ChEMBL 靶标：Serine/threonine-protein kinase TAO2 External Id：CHEMBL4479300

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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