MMRi64

• 常用名: MMRi64
• 英文名: MMRi64
• CAS号: 430458-66-5
• 分子量: 410.298
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₁₇Cl₂N₃O
• 熔点: N/A
• 闪点: N/A

MMRi64用途

MMRi64是一种小分子抑制剂,可在体外破坏Mdm2-MdmX环-环相互作用,激活癌细胞中的p53；有效诱导白血病细胞中Mdm2和MdmX的下调,仅诱导促凋亡基因PUMA(p53上调的细胞凋亡调节剂)的表达,对生长抑制基因p21的诱导最小；选择性诱导白血病/淋巴瘤细胞中p53途径的凋亡臂；协同诱导p53和细胞凋亡与Nutlin3a。

MMRi64名称

• 英文名: MMRi64

MMRi64生物活性

• 描述: MMRi64是一种小分子抑制剂,可在体外破坏Mdm2-MdmX环-环相互作用,激活癌细胞中的p53；有效诱导白血病细胞中Mdm2和MdmX的下调,仅诱导促凋亡基因PUMA(p53上调的细胞凋亡调节剂)的表达,对生长抑制基因p21的诱导最小；选择性诱导白血病/淋巴瘤细胞中p53途径的凋亡臂；协同诱导p53和细胞凋亡与Nutlin3a。
• 参考文献: References 1. Wu W, et al. Cell Death Dis. 2015 Dec 31;6:e2035. View Related Products by Target MDM2-p53

MMRi64物理化学性质

• 分子式: C₂₂H₁₇Cl₂N₃O
• 分子量: 410.298
• InChIKey: HQICAVDTVBACIN-UHFFFAOYSA-N
• SMILES: Cc1ccnc(NC(c2cccc(Cl)c2Cl)c2ccc3cccnc3c2O)c1

MMRi64靶点实验

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实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Glucose transporter External Id：CHEMBL3436044

实验名称：NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL1040691

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 1 External Id：CHEMBL3436042

实验名称：ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania ... 来源：ChEMBL 靶标：Hexose transporter 1 External Id：CHEMBL3436043

实验名称：ST_JUDE: Plasmodium falciparum K1 EC50 (uM) as measured by SYBR green dye 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL730080

实验名称：NOVARTIS: Inhibition Frequency Index (IFI) - the number of HTS assays where a compoun... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1040694

实验名称：ST_JUDE: Plasmodium falciparum 3D7 EC50 (uM) as measured by SYBR green dye 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL730079

实验名称：AlphaScreen Assay from US Patent US9023354: "Combination therapy with MDM2 and EFGR i... 来源：BindingDB 靶标：N/A External Id：BindingDB_6892_1

实验名称：NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in er... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL1040692

实验名称：NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction ... 来源：ChEMBL 靶标：Plasmodium yoelii External Id：CHEMBL1789905

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