HQ-415

• 常用名: HQ-415
• 英文名: HQ-415
• CAS号: 430462-93-4
• 分子量: 415.484
• 密度: 1.2±0.1 g/cm3
• 沸点: 614.9±55.0 °C at 760 mmHg
• 分子式: C₂₅H₂₅N₃O₃
• 熔点: N/A
• 闪点: 325.7±31.5 °C

HQ-415用途

HQ-415是一种与Clioquinol相关的具有生物活性的金属螯合剂, EC50为15 μM。

HQ-415名称

• 中文名: HQ-415
• 英文名: HQ-415

HQ-415生物活性

• 描述: HQ-415是一种与Clioquinol相关的具有生物活性的金属螯合剂, EC50为15 μM。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Tardiff DF, et al. Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms. J Biol Chem. 2012 Feb 3;287(6):4107-4120.

HQ-415物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 614.9±55.0 °C at 760 mmHg
• 分子式: C₂₅H₂₅N₃O₃
• 分子量: 415.484
• 闪点: 325.7±31.5 °C
• 精确质量: 415.189606
• LogP: 4.47
• InChIKey: ZUOOFZJZQYFZQW-UHFFFAOYSA-N
• SMILES: CCOc1cc(C(Nc2cc(C)ccn2)c2ccc3cccnc3c2O)ccc1OC
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.663
• 储存条件: 2-8℃

HQ-415靶点实验

查看更多实验

实验名称：Inhibition of SARS-CoV-2 3CL-Pro proteolytic cleavage of a dual-labeled substrate by ... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL5303714

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Inhibition of SARS-CoV-2 3CL-Pro proteolytic cleavage of a dual-labeled substrate by ... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL5303713

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Biochemical coelenterazine-based NLuc counterscreen for small molecule modulators of ... 来源：NCGC 靶标：N/A External Id：cmt1a-f2-nluc-km-enzymatic

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Biochemical NLuc saturation counterscreen for small molecule modulators of PMP22 gene... 来源：NCGC 靶标：N/A External Id：cmt1a-f2-nluc-enzymatic

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HQ-415英文别名

• 7-{(3-Ethoxy-4-methoxyphenyl)[(4-methyl-2-pyridinyl)amino]methyl}-8-quinolinol