[脱氨基-Cys1,Val4,D-Arg8]-加压素

• 常用名: [脱氨基-Cys1,Val4,D-Arg8]-加压素
• 英文名: (Deamino-Cys1,Val4,D-Arg8)-Vasopressin
• CAS号: 43157-23-9
• 分子量: 1040.22000
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₆H₆₅N₁₃O₁₁S₂
• 熔点: N/A
• 闪点: N/A

[脱氨基-Cys1,Val4,D-Arg8]-加压素用途

[去氨基-4-缬氨酸,8-D-精氨酸]-血管加压素(dVDAVP)是一种高效特异性抗利尿药,具有持久作用[1][2]。

[脱氨基-Cys1,Val4,D-Arg8]-加压素名称

• 中文名: (DEAMINO-CYS1,VAL4,D-ARG8)-VASOPRESSIN
• 英文名: A D Vasopressin

[脱氨基-Cys1,Val4,D-Arg8]-加压素生物活性

• 描述: [去氨基-4-缬氨酸,8-D-精氨酸]-血管加压素(dVDAVP)是一种高效特异性抗利尿药,具有持久作用[1][2]。
• 相关类别:
  研究领域 >> 内分泌
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. M Manning, et al. [1-deaminopenicillamine,4-valine]-8-D-arginine-vasopressin, a highly potent inhibitor of the vasopressor response to arginine-vasopressin. J Med Chem. 1977 Sep;20(9):1228-30.

  [2]. M Manning, et al. Solid phase synthesis of (1-deamino,4-valine)-8-D-arginine-vasopressin (DVDAVP), a highly potent and specific antidiuretic agent possessing protracted effects. J Med Chem. 1973 Sep;16(9):975-8.

[脱氨基-Cys1,Val4,D-Arg8]-加压素物理化学性质

• 分子式: C₄₆H₆₅N₁₃O₁₁S₂
• 分子量: 1040.22000
• 精确质量: 1039.44000
• PSA: 442.92000
• LogP: 2.21370
• InChIKey: KEBRFHAVFOSSOX-WSFLLCRESA-N
• SMILES: CC(C)C1NC(=O)C(Cc2ccccc2)NC(=O)C(Cc2ccc(O)cc2)NC(=O)CCSSCC(C(=O)N2CCCC2C(=O)NC(CCCN=C(N)N)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC1=O

[脱氨基-Cys1,Val4,D-Arg8]-加压素靶点实验

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实验名称：Antidiuretic activity in iv dosed rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3281725

实验名称：Antidiuretic activity in rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL907376

实验名称：Compound was tested for its antidiuretic activity 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL772238

实验名称：Displacement of [3H]AVP from vasopressin V1a receptor in rat liver membrane 来源：ChEMBL 靶标：Vasopressin V1a receptor External Id：CHEMBL907381

实验名称：Vasopressor activity in rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL907377

实验名称：Activity at OT receptor assessed as oxytocic activity in absence of magnesium 来源：ChEMBL 靶标：Oxytocin receptor External Id：CHEMBL907378

实验名称：Displacement of [3H]AVP from vasopressin V2 receptor in rat kidney membranes 来源：ChEMBL 靶标：Vasopressin V2 receptor External Id：CHEMBL907380

实验名称：Antidiuretic activity in iv dosed rat assessed as suppression of urine output relativ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL4397531

实验名称：Tested for intravenous anti-vasopressor pA2 effect in rats 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL797508

实验名称：Tested for intravenous anti-oxytocic effect in the absence of Mg2+ in rats; agonist a... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL797506

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[脱氨基-Cys1,Val4,D-Arg8]-加压素英文别名

• Val4-dDAVP
• [deamino-Cys1,Val4,D-Arg8]-vasopressin
• DVDAVP
• 3-MERCAPTOPROPIONYL-TYR-PHE-VAL-ASN-CYS-PRO-D-ARG-GLY-NH2
• [MPR1,VAL4,DARG8] VASOPRESSIN
• 1-Deamino-4-L-valine-8D-arginine vasopressin
• dVDAVP,(Val4)-DesMopressin
• 2-Deamino-L-Cys(1)-L-Tyr-L-Phe-L-Val-L-Asn-L-Cys(1)-L-Pro-D-Arg-Gly-NH2
• 3-MERCAPTOPROPIONYL-TYR-PHE-VAL-ASN-CYS-PRO-ARG-GLY-NH2
• 1-deamino-4-valine-8-D-arginine-vasopressin
• MPR-TYR-PHE-VAL-ASN-CYS-PRO-DARG-GLY-NH2