LDN 91946

• 常用名: LDN 91946
• 英文名: LDN 91946
• CAS号: 439946-22-2
• 分子量: 314.316
• 密度: 1.6±0.1 g/cm3
• 沸点: 714.0±60.0 °C at 760 mmHg
• 分子式: C₁₇H₁₂N₆O
• 熔点: N/A
• 闪点: 385.6±32.9 °C

LDN 91946用途

LDN 91946是一种选择性,非竞争性泛素C末端水解酶-L1(UCH-L1)抑制剂,Ki为2.8 uM,对其他半胱氨酸水解酶(UCH-L3,TGase 2,木瓜蛋白酶和半胱天冬酶-3)没有活性。

LDN 91946名称

• 中文名: 3-氨基-2-苯甲酰基-6-氧代-6H,7H-噻吩并[2,3-b]吡啶-5-羧酸
• 英文名: LDN-91946

LDN 91946生物活性

• 描述: LDN 91946是一种选择性,非竞争性泛素C末端水解酶-L1(UCH-L1)抑制剂,Ki为2.8 uM,对其他半胱氨酸水解酶(UCH-L3,TGase 2,木瓜蛋白酶和半胱天冬酶-3)没有活性。
• 参考文献: References 1. Mermerian AH, et al. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32. 2. Coulombe J, et al. Front Aging Neurosci. 2014 Jun 19;6:129. View Related Products by Target Deubiquitinase (DUB)

LDN 91946物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 714.0±60.0 °C at 760 mmHg
• 分子式: C₁₇H₁₂N₆O
• 分子量: 314.316
• 闪点: 385.6±32.9 °C
• 精确质量: 314.036133
• LogP: 2.20
• 外观性状: 固体
• 蒸汽压: 0.0±2.4 mmHg at 25°C
• 折射率: 1.722
• 储存条件: 2-8°C，密封，干燥

LDN 91946靶点实验

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实验名称：Selectivity for UCHL1 (unknown origin) over UCHL3 (unknown origin) 来源：ChEMBL 靶标：N/A External Id：CHEMBL3412291

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：High-throughput screen for inhibitors of the GIV GBA-motif interaction with Galpha-i ... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS1303

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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LDN 91946英文别名

• 3-Amino-2-benzoyl-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carboxylic acid
• LDN-91946
• MFCD03016619