K00546

• 常用名: K00546
• 英文名: K00546
• CAS号: 443798-47-8
• 分子量: 425.436
• 密度: 1.7±0.1 g/cm3
• 沸点: 649.1±65.0 °C at 760 mmHg
• 分子式: C₁₅H₁₃F₂N₇O₂S₂
• 熔点: N/A
• 闪点: 346.4±34.3 °C

K00546用途

K00546是CDC2样激酶CLK1和CLK3的有效抑制剂,IC50分别为8.9和29.2nM。

K00546名称

• 英文名: K-00546

K00546生物活性

• 描述: K00546是CDC2样激酶CLK1和CLK3的有效抑制剂,IC50分别为8.9和29.2nM。
• 参考文献: References 1. Fedorov O, et al. Chem Biol. 2011 Jan 28;18(1):67-76. 2. Prak K, et al. Biochemistry. 2016 Jan 26;55(3):608-17. View Related Products by Target Cdc2-like Kinase (CLK)

K00546物理化学性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 649.1±65.0 °C at 760 mmHg
• 分子式: C₁₅H₁₃F₂N₇O₂S₂
• 分子量: 425.436
• 闪点: 346.4±34.3 °C
• 精确质量: 425.054016
• LogP: 1.27
• InChIKey: ARIOBGGRZJITQX-UHFFFAOYSA-N
• SMILES: Nc1nc(Nc2ccc(S(N)(=O)=O)cc2)nn1C(=S)Nc1c(F)cccc1F
• 蒸汽压: 0.0±1.9 mmHg at 25°C
• 折射率: 1.755

K00546靶点实验

查看更多实验

实验名称：Human fms related tyrosine kinase 1 (Type IV RTKs: VEGF (vascular endothelial growth ... 来源：IUPHAR-DB 靶标：fms related tyrosine kinase 1 (Type IV RTKs: VEGF (vascular endothelial growth factor) receptor family) [Homo sapiens] External Id：1812_Human

实验名称：Delta TM value showing the stabilisation of CAMK2G produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit gamma External Id：CHEMBL3430795

实验名称：Delta TM value showing the stabilisation of CAMK4 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type IV External Id：CHEMBL3430796

实验名称：Delta TM value showing the stabilisation of CAMK2B produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit beta External Id：CHEMBL3430793

实验名称：Delta TM value showing the stabilisation of CAMK2D produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit delta External Id：CHEMBL3430794

实验名称：Delta TM value showing the stabilisation of CDK6 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase 6 External Id：CHEMBL3430799

实验名称：Delta TM value showing the stabilisation of CDKL1 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase-like 1 External Id：CHEMBL3430800

实验名称：Delta TM value showing the stabilisation of CAMKK2 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase kinase 2 External Id：CHEMBL3430797

实验名称：Delta TM value showing the stabilisation of CDK2 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL3430798

实验名称：Delta TM value showing the stabilisation of CLK2 produced by compound binding 来源：ChEMBL 靶标：Dual specificity protein kinase CLK2 External Id：CHEMBL3430803

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K00546英文别名

• MFCD09264159
• LFR1253W75
• CDK1/2 Inhibitor III
• K-00546
• 5-Amino-N-(2,6-difluorophenyl)-3-[(4-sulfamoylphenyl)amino]-1H-1,2,4-triazole-1-carbothioamide