6-(2,4-二氟苯氧基)-8-甲基-2-[(四氢-2H-吡喃-4-基)氨基]-吡啶并[2,3-d]嘧啶-7(8h)-酮

• 常用名: 6-(2,4-二氟苯氧基)-8-甲基-2-[(四氢-2H-吡喃-4-基)氨基]-吡啶并[2,3-d]嘧啶-7(8h)-酮
• 英文名: R1487
• CAS号: 449811-92-1
• 分子量: 388.36800
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₈F₂N₄O₃
• 熔点: N/A
• 闪点: N/A

用途

R1487 is a p38 MAP kinase inhibitor with an IC50 of 10nM. It may have potential as a treatment for inflammatory diseases such as rheumatoid arthritis.

名称

• 中文名: 6-(2,4-二氟苯氧基)-8-甲基-2-[(四氢-2H-吡喃-4-基)氨基]-吡啶并[2,3-d]嘧啶-7(8h)-酮
• 英文名: 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino )pyrido[2,3-d]pyrimidin-7(8H)-one

物理化学性质

• 分子式: C₁₉H₁₈F₂N₄O₃
• 分子量: 388.36800
• 精确质量: 388.13500
• PSA: 81.50000
• LogP: 2.41180
• 储存条件: -20°C，密闭，干燥

英文别名

• 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one
• [14C]-R1487
• 6-(2,4-Difluorophenoxy)-2-{[3-Hydroxy-1-(2-Hydroxyethyl)propyl]amino}-8-Methylpyrido[2,3-D]pyrimidin-7(8h)-One
• 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
• Pamapimod (INN/USAN)
• Pamapimod
• [14C]-Pamapimod
• 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
• R1487