6-(2,4-二氟苯氧基)-8-甲基-2-[(四氢-2H-吡喃-4-基)氨基]-吡啶并[2,3-d]嘧啶-7(8h)-酮

• 常用名: 6-(2,4-二氟苯氧基)-8-甲基-2-[(四氢-2H-吡喃-4-基)氨基]-吡啶并[2,3-d]嘧啶-7(8h)-酮
• 英文名: R1487
• CAS号: 449811-92-1
• 分子量: 388.36800
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₈F₂N₄O₃
• 熔点: N/A
• 闪点: N/A

用途

R1487 is a p38 MAP kinase inhibitor with an IC50 of 10nM. It may have potential as a treatment for inflammatory diseases such as rheumatoid arthritis.

名称

• 中文名: 6-(2,4-二氟苯氧基)-8-甲基-2-[(四氢-2H-吡喃-4-基)氨基]-吡啶并[2,3-d]嘧啶-7(8h)-酮
• 英文名: 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino )pyrido[2,3-d]pyrimidin-7(8H)-one

物理化学性质

• 分子式: C₁₉H₁₈F₂N₄O₃
• 分子量: 388.36800
• 精确质量: 388.13500
• PSA: 81.50000
• LogP: 2.41180
• InChIKey: KKKRKRMVJRHDMG-UHFFFAOYSA-N
• SMILES: Cn1c(=O)c(Oc2ccc(F)cc2F)cc2cnc(NC3CCOCC3)nc21
• 储存条件: -20°C，密闭，干燥

靶点实验

查看更多实验

实验名称：Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident pro... 来源：NCGC 靶标：N/A External Id：SERCaMPGLuc-p1-antagonist

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Tmax in cynomolgus monkey at 10 mg/kg, po 来源：ChEMBL 靶标：Macaca fascicularis External Id：CHEMBL1769347

实验名称：AUC (infinity) in cynomolgus monkey at 10 mg/kg, po 来源：ChEMBL 靶标：Macaca fascicularis External Id：CHEMBL1769350

实验名称：Primary qHTS for Identification of Small Molecule Activators of Huntingtin-Antisense ... 来源：NCGC External Id：huntington-HTTAS8-p1-FF-overN

实验名称：Half life in cynomolgus monkey at 10 mg/kg, po 来源：ChEMBL 靶标：Macaca fascicularis External Id：CHEMBL1769349

实验名称：Inhibition of LPS-induced TNFalpha production in rat serum at 3 mg/kg, po administere... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1769335

实验名称：Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry 来源：NCGC 靶标：N/A External Id：TRND-SARS-CoV-2-cytotox-48hr

实验名称：Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry 来源：NCGC External Id：TRND-SARS-CoV-2-PP

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

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英文别名

• 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)-propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidine-7-one
• [14C]-R1487
• 6-(2,4-Difluorophenoxy)-2-{[3-Hydroxy-1-(2-Hydroxyethyl)propyl]amino}-8-Methylpyrido[2,3-D]pyrimidin-7(8h)-One
• 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one
• Pamapimod (INN/USAN)
• Pamapimod
• [14C]-Pamapimod
• 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one
• R1487