GSK-3抑制剂II

• 常用名: GSK-3抑制剂II
• 英文名: GSK3β inhibitor II
• CAS号: 478482-75-6
• 分子量: 395.21800
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₀IN₃OS
• 熔点: N/A
• 闪点: N/A

GSK-3抑制剂II用途

GSK3β抑制剂II是一种GSK3α的抑制剂。GSK3β抑制剂II可用于阿尔茨海默病(AD)的研究[1]。

GSK-3抑制剂II名称

• 中文名: GSK-3抑制剂II
• 英文名: 2-[(3-iodophenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole

GSK-3抑制剂II生物活性

• 描述: GSK3β抑制剂II是一种GSK3α的抑制剂。GSK3β抑制剂II可用于阿尔茨海默病(AD)的研究[1]。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> GSK-3
  研究领域 >> 神经疾病
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> GSK-3
• 靶点实验:

  GSK-3β

• 体外研究: GSK3β抑制剂II与 Ile62、Phe67、Val70、Ala83和 亮氨酸188具有疏水相互作用,与 赖氨酸85具有离子相互作用,以及与 赖氨酸85和 阀门135残基具有氢键相互作用[1]。 GSK3β抑制剂II与 阀门135[1]形成氢键。
• 参考文献:

  [1]. Elangovan ND, et al. Screening of potential drug for Alzheimer's disease: a computational study with GSK-3 β inhibition through virtual screening, docking, and molecular dynamics simulation. J Biomol Struct Dyn. 2021 Nov;39(18):7065-7079.

GSK-3抑制剂II物理化学性质

• 分子式: C₁₄H₁₀IN₃OS
• 分子量: 395.21800
• 精确质量: 394.95900
• PSA: 77.11000
• LogP: 4.02850
• InChIKey: ZRHRPGSSSVYBRG-UHFFFAOYSA-N
• SMILES: Ic1cccc(CSc2nnc(-c3ccncc3)o2)c1

GSK-3抑制剂II靶点实验

查看更多实验

实验名称：Delta TM value showing the stabilisation of CAMK2G produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit gamma External Id：CHEMBL3430795

实验名称：Delta TM value showing the stabilisation of CAMK4 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type IV External Id：CHEMBL3430796

实验名称：Delta TM value showing the stabilisation of CAMK2B produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit beta External Id：CHEMBL3430793

实验名称：Delta TM value showing the stabilisation of CAMK2D produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit delta External Id：CHEMBL3430794

实验名称：Delta TM value showing the stabilisation of CDK6 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase 6 External Id：CHEMBL3430799

实验名称：Delta TM value showing the stabilisation of CDKL1 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase-like 1 External Id：CHEMBL3430800

实验名称：Delta TM value showing the stabilisation of CAMKK2 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase kinase 2 External Id：CHEMBL3430797

实验名称：Delta TM value showing the stabilisation of CDK2 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase 2 External Id：CHEMBL3430798

实验名称：Delta TM value showing the stabilisation of CLK2 produced by compound binding 来源：ChEMBL 靶标：Dual specificity protein kinase CLK2 External Id：CHEMBL3430803

实验名称：Delta TM value showing the stabilisation of CLK3 produced by compound binding 来源：ChEMBL 靶标：Dual specificity protein kinase CLK3 External Id：CHEMBL3430804

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GSK-3抑制剂II英文别名

• GSK-3b Inhibitor II
• Glycogen Synthase Kinase-3beta Inhibitor II
• GSK-3 Inhibitor II
• GSK-3beta Inhibitor II
• 2-(3-iodobenzylthio)-5-(pyridin-4-yl)-1,3,4-oxadiazole
• 2-thio(3-iodobenzyl)-5-(1-pyridyl)-[1,3,4]oxadiazole
• HMS3229G14