共轭雌激素

• 常用名: 共轭雌激素
• 英文名: 3-hydroxyestra-1,3,5(10)-trien-17-one hydrogen sulphate
• CAS号: 481-97-0
• 分子量: 349.42100
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₂₁O₅S-
• 熔点: N/A
• 闪点: N/A

共轭雌激素用途

硫酸雌酮是血液中存在的内源性代谢产物,可用于X连锁鱼鳞病和肥胖症的研究[1][2][3]。

共轭雌激素名称

• 中文名: 共轭雌激素
• 英文名: estrone 3-sulfate

共轭雌激素生物活性

• 描述: 硫酸雌酮是血液中存在的内源性代谢产物,可用于X连锁鱼鳞病和肥胖症的研究[1][2][3]。
• 相关类别:
  研究领域 >> 代谢疾病
• 靶点实验:

  Human Endogenous Metabolite

• 体外研究: 内源性代谢产物被定义为《京都基因和基因组百科全书》注释为我们基因组中约1900种代谢酶的底物或产物。在文献正文中很清楚,许多这些代谢产物都具有毒性[1]。
• 参考文献:

  [1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

  [2]. Lykkesfeldt G, et al. Abnormal androgen and oestrogen metabolism in men with steroid sulphatase deficiency and recessive X-linked ichthyosis. Clin Endocrinol (Oxf). 1985 Oct;23(4):385-93.

  [3]. Brind J, et al. Obese men have elevated plasma levels of estrone sulfate. Int J Obes. 1990 Jun;14(6):483-6.

共轭雌激素物理化学性质

• 分子式: C₁₈H₂₁O₅S-
• 分子量: 349.42100
• 精确质量: 349.11100
• PSA: 91.88000
• LogP: 4.03160
• InChIKey: JKKFKPJIXZFSSB-CBZIJGRNSA-N
• SMILES: CC12CCC3c4ccc(OS(=O)(=O)O)cc4CCC3C1CCC2=O
• 储存条件: -20°C

共轭雌激素靶点实验

查看更多实验

实验名称：TP_TRANSPORTER: uptake in BCRP-expressing LLC-PK1 cells 来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2 External Id：CHEMBL2075585

实验名称：Apparent permeability from apical to basolateral side of vector transfected human Cac... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3539198

实验名称：Apparent permeability from basolateral to apical side of vector transfected human Cac... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3539199

实验名称：Inhibition of VGLUT-mediated [3H]-L-Glu uptake into synaptic vesicles in rat brain 来源：ChEMBL 靶标：N/A External Id：CHEMBL3119491

实验名称：TP_TRANSPORTER: cell accumulation in OATP2-expressing HEK293 cells 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1B1 External Id：CHEMBL2076471

实验名称：TP_TRANSPORTER: uptake (pH 7.4) of Estrone-3-sulfate at a concentration of 5.43 nM in... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 2B1 External Id：CHEMBL2077200

实验名称：Inhibition of VGLUT in rat brain assessed as [3H]-L-Glu uptake into synaptic vesicles... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3119492

实验名称：TP_TRANSPORTER: uptake in OATP-D-expressing HEK293 cells 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 3A1 External Id：CHEMBL2076477

实验名称：Drug uptake in mouse Astrocyte cells expressing OATPIC4/5/6 at 100 uM incubated for 3... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5392421

实验名称：TP_TRANSPORTER: inhibition of Ochratoxin A uptake (OTA: 1 uM, E1S: 100uM) in Xenopus ... 来源：ChEMBL 靶标：Solute carrier organic anion transporter family member 1A1 External Id：CHEMBL2076391

共175条，当前第1页，共18页

1

2

3

4

5

共轭雌激素英文别名

• estrone-3-sulfate