Dcg066

• 常用名: Dcg066
• 英文名: Dcg066
• CAS号: 494786-13-9
• 分子量: 579.58
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₃₁F₆N₃O₂
• 熔点: N/A
• 闪点: N/A

Dcg066用途

DCG066是一种G9a体外抑制剂。

Dcg066名称

• 英文名: DCG066

Dcg066生物活性

• 描述: DCG066是一种G9a体外抑制剂。
• 参考文献: 1. Kondengaden SM, Luo LF, Huang K, Zhu M, Zang L, Bataba E, Wang R, Luo C, Wang B, Li KK, Wang PG. Discovery of novel small molecule inhibitors of lysine methyltransferase G9a and their mechanism in leukemia cell lines. Eur J Med Chem. 2016 Oct 21;122:382-393. doi: 10.1016/j.ejmech.2016.06.028. Epub 2016 Jun 21. PubMed PMID: 27393948.

Dcg066物理化学性质

• 分子式: C₃₀H₃₁F₆N₃O₂
• 分子量: 579.58
• InChIKey: PMPKMTDYPOAEEH-UHFFFAOYSA-N
• SMILES: CN(C)C(=O)Nc1ccc(CN2CCC(C(O)(c3ccc(C(F)(F)F)cc3)c3ccc(C(F)(F)F)cc3)CC2)cc1

Dcg066靶点实验

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实验名称：Inhibition of G9a (unknown origin) 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT2 External Id：CHEMBL5392898

实验名称：Inhibition of histone methyltransferase G9a in human K562 cells assessed as reduction... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT2 External Id：CHEMBL3866565

实验名称：Inhibition of histone H3K27 trimethylation in human K562 cells at 1 to 2 uM after 72 ... 来源：ChEMBL 靶标：K562 External Id：CHEMBL3866566

实验名称：Inhibition of His-sumo-tagged BALB/c mouse thymus histone methyltransferase G9a (969 ... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT2 External Id：CHEMBL3866560

实验名称：Inhibition of His-sumo-tagged BALB/c mouse thymus histone methyltransferase G9a (969 ... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT2 External Id：CHEMBL3866555

实验名称：Inhibition of His-sumo-tagged BALB/c mouse thymus histone methyltransferase G9a (969 ... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT2 External Id：CHEMBL3866556

实验名称：Inhibition of histone methyltransferase G9a (unknown origin) assessed as growth inhib... 来源：ChEMBL 靶标：Histone-lysine N-methyltransferase EHMT2 External Id：CHEMBL3866557

实验名称：Induction of apoptosis in human K562 cells at 2 uM after 24 hrs by Annexin V-PE/7AAD-... 来源：ChEMBL 靶标：K562 External Id：CHEMBL3866567

实验名称：Cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase up to 4 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3866568

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