EN460

• 常用名: EN460
• 英文名: EN460
• CAS号: 496807-64-8
• 分子量: 460.79
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₁₂ClF₃N₂O₄
• 熔点: N/A
• 闪点: N/A

EN460用途

EN460是ERO1小分子抑制剂,IC50值1.9uM。

EN460名称

• 中文名: EN460
• 英文名: en460

EN460生物活性

• 描述: EN460是ERO1小分子抑制剂,IC50值1.9uM。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 其他
• 参考文献:

  [1]. Blais JD, et al. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285(27):20993-1003.

EN460物理化学性质

• 分子式: C₂₂H₁₂ClF₃N₂O₄
• 分子量: 460.79
• PSA: 56.40000
• LogP: 3.28560
• InChIKey: RSLFQCNAOMQAIH-WJDWOHSUSA-N
• SMILES: O=C(O)c1cc(N2N=C(C(F)(F)F)C(=Cc3ccc(-c4ccccc4)o3)C2=O)ccc1Cl
• 储存条件: 2-8℃

EN460靶点实验

查看更多实验

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Competitive inhibition of recombinant human Ero1Lalpha C104A/C131A/C166A triple mutan... 来源：ChEMBL 靶标：ERO1-like protein alpha External Id：CHEMBL4321224

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：A screen for compounds that inhibit viral RNA polymerase binding and polymerization a... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Chain A, Poliovirus Polymerase With Gtp External Id：HMS750

实验名称：Solubility of the compound at >200 uM 来源：ChEMBL 靶标：N/A External Id：CHEMBL4321234

实验名称：Binding affinity to recombinant human Ero1Lalpha C104A/C131A/C166A triple mutant (22 ... 来源：ChEMBL 靶标：ERO1-like protein alpha External Id：CHEMBL4321232

实验名称：Binding affinity to recombinant human His-tagged PDI (18 to 479 residues) expressed i... 来源：ChEMBL 靶标：Protein disulfide-isomerase External Id：CHEMBL4321231

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