Cdk2/9抑制剂

• 常用名: Cdk2/9抑制剂
• 英文名: CK7
• CAS号: 507487-89-0
• 分子量: 328.34900
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₂N₆O₂S
• 熔点: N/A
• 闪点: N/A

Cdk2/9抑制剂用途

CK7是一种Cdk2/9抑制剂,可用于合成Nek1抑制剂BSc5231和BSc5367[1]。

Cdk2/9抑制剂名称

• 中文名: Cdk2/9抑制剂
• 英文名: 4-methyl-5-[2-(3-nitroanilino)pyrimidin-4-yl]-1,3-thiazol-2-amine

Cdk2/9抑制剂生物活性

• 描述: CK7是一种Cdk2/9抑制剂,可用于合成Nek1抑制剂BSc5231和BSc5367[1]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 细胞周期/DNA损伤 >> CDK
• 靶点实验:

  CDK2

  CDK9

• 参考文献:

  [1]. Pilakowski J, et al. Design, synthesis and biological evaluation of novel aminopyrazole- and 7-azaindole-based Nek1 inhibitors and their effects on zebrafish kidney development. Bioorg Med Chem Lett. 2021;53:128418.

Cdk2/9抑制剂物理化学性质

• 分子式: C₁₄H₁₂N₆O₂S
• 分子量: 328.34900
• 精确质量: 328.07400
• PSA: 151.51000
• LogP: 3.66880
• InChIKey: DYTKVFHLKPDNRW-UHFFFAOYSA-N
• SMILES: Cc1nc(N)sc1-c1ccnc(Nc2cccc([N+](=O)[O-])c2)n1

Cdk2/9抑制剂靶点实验

查看更多实验

实验名称：Selectivity ratio of Ki for human recombinant Aurora B to Ki for CDK9 来源：ChEMBL 靶标：N/A External Id：CHEMBL1119873

实验名称：Selectivity ratio of Ki for human recombinant Aurora B to Ki for CDK2 来源：ChEMBL 靶标：N/A External Id：CHEMBL1119872

实验名称：Selectivity ratio of Ki for human recombinant Aurora A to Ki for CDK9 来源：ChEMBL 靶标：N/A External Id：CHEMBL1119871

实验名称：Selectivity ratio of Ki for human recombinant Aurora A to Ki for CDK2 来源：ChEMBL 靶标：N/A External Id：CHEMBL1119488

实验名称：CDK Kinase Inhibition Assay from Article 10.1021/jm0309957: "2-Anilino-4-(thiazol-5-y... 来源：BindingDB 靶标：N/A External Id：BindingDB_1010_1

实验名称：Cytotoxicity against human MIAPaCa2 cells after 96 hrs by MTT assay 来源：ChEMBL 靶标：MIA PaCa-2 External Id：CHEMBL1119486

实验名称：Cytotoxicity against human A2780 cells after 96 hrs by MTT assay 来源：ChEMBL 靶标：A2780 External Id：CHEMBL1119485

实验名称：Inhibition of Cdk2/ cyclin E 来源：ChEMBL 靶标：N/A External Id：CHEMBL936788

实验名称：Delta TM value showing the stabilisation of CAMK2G produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit gamma External Id：CHEMBL3430795

实验名称：Delta TM value showing the stabilisation of CAMK4 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type IV External Id：CHEMBL3430796

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Cdk2/9抑制剂英文别名

• 2wev
• CK7
• 2c5p
• 1pxo
• Cdk2/9 Inhibitor