GSK-3β inhibitor 11

• 常用名: GSK-3β inhibitor 11
• 英文名: GSK-3β inhibitor 11
• CAS号: 536731-65-4
• 分子量: 393.416
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₀H₁₅N₃O₄S
• 熔点: N/A
• 闪点: N/A

GSK-3β inhibitor 11用途

GSK-3β抑制剂11(化合物21)是一种糖原合成酶激酶-3β(GSK-3？)抑制剂(IC50=10.02μM)。GSK-3β抑制剂11可用于神经退行性疾病的研究[1]。

GSK-3β inhibitor 11名称

• 英文名: 2H-Isoindole-2-acetamide, 1,3-dihydro-N-[4-(3-methoxyphenyl)-2-thiazolyl]-1,3-dioxo

GSK-3β inhibitor 11生物活性

• 描述: GSK-3β抑制剂11(化合物21)是一种糖原合成酶激酶-3β(GSK-3？)抑制剂(IC50=10.02μM)。GSK-3β抑制剂11可用于神经退行性疾病的研究[1]。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> GSK-3
  研究领域 >> 神经疾病
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> GSK-3
• 靶点实验:

  GSK-3β:10.02 μM (IC50)

• 参考文献:

  [1]. Fu G, et al. Pharmacophore Modeling, Ensemble Docking, Virtual Screening, and Biological Evaluation on Glycogen Synthase Kinase-3β. Mol Inform. 2014 Sep;33(9):610-26.

GSK-3β inhibitor 11物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₀H₁₅N₃O₄S
• 分子量: 393.416
• 精确质量: 393.078339
• LogP: 3.76
• InChIKey: OLPPQDIVHUSKKX-UHFFFAOYSA-N
• SMILES: COc1cccc(-c2csc(NC(=O)CN3C(=O)c4ccccc4C3=O)n2)c1
• 折射率: 1.686
• 储存条件: -20°C

GSK-3β inhibitor 11靶点实验

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实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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GSK-3β inhibitor 11英文别名

• 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-N-[4-(3-methoxyphenyl)-1,3-thiazol-2-yl]acetamide