益多酯

• 常用名: 益多酯
• 英文名: etofylline clofibrate
• CAS号: 54504-70-0
• 分子量: 420.847
• 密度: 1.4±0.1 g/cm3
• 沸点: 615.8±65.0 °C at 760 mmHg
• 分子式: C₁₉H₂₁ClN₄O₅
• 熔点: 133-135°
• 闪点: 326.2±34.3 °C

益多酯用途

Etofylline clofibrate 具有降脂和抗血栓形成作用。Etofylline clofibrate 具有与内膜 PGI2 激动的相互作用。

益多酯名称

• 中文名: 益多酯
• 英文名: 2-(1,3-dimethyl-2,6-dioxopurin-7-yl)ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
• 中文别名: 乙羟茶碱安妥明酯

益多酯生物活性

• 描述: Etofylline clofibrate 具有降脂和抗血栓形成作用。Etofylline clofibrate 具有与内膜 PGI2 激动的相互作用。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 体内研究: 依托普林氯贝特酯(P.O；12 mg/kg)具有单一剂量的中度效应(解聚时间的12%减少),分别在5次和7次连续应用后分别最大降低31和43% [1 ]。
• 参考文献:

  [1]. Metz G, et al. Effect of etofylline clofibrate on experimental thrombus formation and prostacyclin activation. Arzneimittelforschung. 1986 Sep;36(9):1363-5.

益多酯物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 615.8±65.0 °C at 760 mmHg
• 熔点: 133-135°
• 分子式: C₁₉H₂₁ClN₄O₅
• 分子量: 420.847
• 闪点: 326.2±34.3 °C
• 精确质量: 420.120056
• PSA: 97.35000
• LogP: 2.75
• InChIKey: KYAKGJDISSNVPZ-UHFFFAOYSA-N
• SMILES: Cn1c(=O)c2c(ncn2CCOC(=O)C(C)(C)Oc2ccc(Cl)cc2)n(C)c1=O
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.618

益多酯毒性和生态

益多酯靶点实验

查看更多实验

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Counterscreen for inhibitors of the fructose-bisphosphate aldolase (FBA) of M. tuberc... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：GDH-TPI_INH_ABS_1536_1X%INH CSRUN

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296192

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296783

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益多酯英文别名

• 2-(4-Chlorophenoxy)-2-methylpropanoic Acid 2-(1,2,3,6-Tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl Ester
• etofylline clofibrate
• etofyllinclofibrate
• Theofibrate
• Propanoic acid, 2-(4-chlorophenoxy)-2-methyl-, 2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl ester
• 2-(p-Chlorophenoxy)-2-methylpropionic acid 2-(7-theophyllinyl)ethyl ester
• 2-(p-Chlorophenoxy)-2-methylpropionic Acid Ester with 7-(2-Hydroxyethyl)theophylline
• Propionic acid, 2-(p-chlorophenoxy)-2-methyl-, 2-(7-theophyllinyl)ethyl ester
• Etofyllinclofibrat
• 2-(1,3-Dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
• Duolip
• 2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin-7-yl)ethyl 2-[(4-chlorophenyl)oxy]-2-methylpropanoate