Sarcophine

• 常用名: Sarcophine
• 英文名: Sarcophine
• CAS号: 55038-27-2
• 分子量: 316.43500
• 密度: 1.08g/cm3
• 沸点: 472.8ºC at 760 mmHg
• 分子式: C₂₀H₂₈O₃
• 熔点: N/A
• 闪点: 203.5ºC

Sarcophine用途

肌黄嘌呤((+)-肌黄嘌呤)是一种有效的甘氨酸受体(GlyR)抑制剂,IC50值为3.9μM。石灰质是一种天然产物,可以从红海软珊瑚石灰质中分离出来[1]。

Sarcophine名称

• 英文名: Sarcophine

Sarcophine生物活性

• 描述: 肌黄嘌呤((+)-肌黄嘌呤)是一种有效的甘氨酸受体(GlyR)抑制剂,IC50值为3.9μM。石灰质是一种天然产物,可以从红海软珊瑚石灰质中分离出来[1]。
• 相关类别:
  研究领域 >> 神经疾病
• 体外研究: 肌松((+)-肌松)是一种重组甘氨酸受体抑制剂,Ki公司值为 2.1μM[1]石竹碱(1-100 mM；24小时)对 HEK293型细胞具有细胞毒性,LD50型值为 29.3毫摩尔[1]
• 参考文献:

  [1]. Saleh HA, et, al. Sarcophine and (7S, 8R)-dihydroxydeepoxysarcophine from the Red Sea soft coral Sarcophyton glaucum as in vitro and in vivo modulators of glycine receptors. Neurotoxicology. 2020 Sep;80:105-111.

Sarcophine物理化学性质

• 密度: 1.08g/cm3
• 沸点: 472.8ºC at 760 mmHg
• 分子式: C₂₀H₂₈O₃
• 分子量: 316.43500
• 闪点: 203.5ºC
• 精确质量: 316.20400
• PSA: 38.83000
• LogP: 4.63260
• InChIKey: CGAKBBMRMLAYMY-QLOJAFMTSA-N
• SMILES: CC1=CCCC2(C)OC2CCC(C)=CC2OC(=O)C(C)=C2CC1
• 折射率: 1.536

Sarcophine毒性和生态

Sarcophine靶点实验

查看更多实验

实验名称：Antiproliferative activity against human MDA-MB-231 cells at 5 to 50 uM after 24 hrs ... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL1816444

实验名称：Antiproliferative activity against human PC3 cells at 5 to 50 uM after 24 hrs by MTT ... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL1816446

实验名称：Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL949831

实验名称：Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL949830

实验名称：Reduction in human pancreatic recombinant 1B PLA2 activity expressed in Escherichia c... 来源：ChEMBL 靶标：Phospholipase A2 External Id：CHEMBL1026212

实验名称：Cytotoxicity against human Raji cells assessed as cell viability at 500 molar ratio 来源：ChEMBL 靶标：Raji External Id：CHEMBL949833

实验名称：Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio 来源：ChEMBL 靶标：Raji External Id：CHEMBL949832

实验名称：Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL949829

实验名称：Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL949828

实验名称：Inhibition of residual DNA repair ability in Homo sapiens (human) MCF7 cells assessed... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL3056897

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Sarcophine英文别名

• Oxireno(9,10)cyclotetradeca(1,2-B)furan-9(1ah)-one,2,3,6,7,10A,13,14,14A-octahydro-1A,5,8,12-tetramethyl-(van) (9ci)
• (1aS,4E,10aS,11E,14aS)-2,3,6,7,10a,13,14,14a-Octahydro-1a,5,8,12-tetramethyloxireno[9,10]cyclotetradeca[1,2-b]furan-9(1aH)-one
• Sarcophyne
• Sarcophin
• Oxireno(9,10)cyclotetradeca(1,2-B)furan-9(1ah)-one,2,3,6,7,10A,13,14,14A-octahydro-1A,5,8,12-tetramethyl-,(1as-(1ar*,4E,10ar*,11E,14ar*))
• Sarcophin a