吡咯他尼

• 常用名: 吡咯他尼
• 英文名: Piretanide
• CAS号: 55837-27-9
• 分子量: 362.40000
• 密度: 1.415 g/cm3
• 沸点: 597.7ºC at 760 mmHg
• 分子式: C₁₇H₁₈N₂O₅S
• 熔点: 225-227°C (lit.)
• 闪点: 315.3ºC

吡咯他尼用途

吡雷他尼是一种口服活性、相对安全有效的利尿剂。吡雷他尼有可能用于充血性心力衰竭的研究,其潜在优势是具有保钾特性。吡雷他尼也可用于高血压的研究[1][2]。

吡咯他尼名称

• 中文名: 吡咯他尼
• 英文名: 4-phenoxy-3-pyrrolidin-1-yl-5-sulfamoylbenzoic acid
• 中文别名: 4-苯氧基-3-吡咯烷-1-基-5-氨基磺酰基苯甲酸 | 苯氧吡酸

吡咯他尼生物活性

• 描述: 吡雷他尼是一种口服活性、相对安全有效的利尿剂。吡雷他尼有可能用于充血性心力衰竭的研究,其潜在优势是具有保钾特性。吡雷他尼也可用于高血压的研究[1][2]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Carda-Broch S, et al. Analysis of urine samples containing cardiovascular drugs by micellar liquid chromatography with fluorimetric detection. J Chromatogr Sci. 1999;37(4):93-102.

  [2]. Sherman LG, et al. Piretanide, a potent diuretic with potassium-sparing properties, for the treatment of congestive heart failure. Clin Pharmacol Ther. 1986;40(5):587-594.

吡咯他尼物理化学性质

• 密度: 1.415 g/cm3
• 沸点: 597.7ºC at 760 mmHg
• 熔点: 225-227°C (lit.)
• 分子式: C₁₇H₁₈N₂O₅S
• 分子量: 362.40000
• 闪点: 315.3ºC
• 精确质量: 362.09400
• PSA: 118.31000
• LogP: 4.27080
• InChIKey: UJEWTUDSLQGTOA-UHFFFAOYSA-N
• SMILES: NS(=O)(=O)c1cc(C(=O)O)cc(N2CCCC2)c1Oc1ccccc1
• 外观性状: 淡黄色粉末
• 折射率: 1.64
• 储存条件: 2-8°C

吡咯他尼毒性和生态

吡咯他尼安全信息

• 海关编码: 2935009090

吡咯他尼海关

• 海关编码: 2935009090
• 中文概述: 2935009090 其他磺（酰）胺. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:35.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

吡咯他尼靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu... 来源：824 External Id：CYP273

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity 来源：NCGC External Id：HERG01

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen 来源：NCGC 靶标：N/A External Id：SMAD3201

实验名称：uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay 来源：Burnham Center for Chemical Genomics 靶标：cystic fibrosis transmembrane conductance regulator [Homo sapiens] External Id：SBCCG-A764-CF-PAF-Primary-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ant... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_ANT_FLUO8_1536_1X%INH PRUN

实验名称：qHTS for Inhibitors of TGF-b 来源：NCGC 靶标：Smad3 [Homo sapiens] External Id：SMAD3101

实验名称：Primary qHTS for inhibitors of NSP2Pro chikungunya virus (CHIKV) 来源：NCGC External Id：APP-Toga-CHIKV-nsp2-p

共482条，当前第1页，共49页

1

2

3

4

5

吡咯他尼英文别名

• Tauliz
• Piretanido [Spanish]
• Piretanido [INN-Spanish]
• Hoe-118
• Piretanidum [INN-Latin]
• MFCD00867334
• 4-phenoxy-3(1-pyrrolidinyl)-5-sulfamoylbenzoic acid
• EINECS 259-852-9
• 4-phenoxy-3-(pyrrolidin-1-yl)-5-sulfamoylbenzoic acid
• Arelix (TN)
• piretanide
• 3-(1-pyrrolidinyl)-4-phenoxy-5-sulfamylbenzoic acid