2-(6-hydrazinylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

• 常用名: 2-(6-hydrazinylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• 英文名: 2-(6-hydrazinylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
• CAS号: 5746-27-0
• 分子量: 282.26
• 密度: 2.12g/cm3
• 沸点: 723.5ºC at 760mmHg
• 分子式: C₁₀H₁₄N₆O₄
• 熔点: N/A
• 闪点: 391.4ºC

用途

N6-氨基腺苷是一种腺苷类似物。腺苷类似物主要起到平滑肌血管扩张剂的作用,也被证明可以抑制癌症的进展。该系列中流行的产品有磷酸腺苷、阿卡地辛(HY-13417)、氯法拉滨(HY-A0005)、磷酸氟达拉滨(HY-B0028)和维达拉宾(HY-B0277)[1]。

名称

• 英文名: 9H-Purine, 6-hydrazino-9-.β.-D-ribofuranosyl

生物活性

• 描述: N6-氨基腺苷是一种腺苷类似物。腺苷类似物主要起到平滑肌血管扩张剂的作用,也被证明可以抑制癌症的进展。该系列中流行的产品有磷酸腺苷、阿卡地辛(HY-13417)、氯法拉滨(HY-A0005)、磷酸氟达拉滨(HY-B0028)和维达拉宾(HY-B0277)[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
  研究领域 >> 其他
• 参考文献:

  [1]. Man S, et al. Potential and promising anticancer drugs from adenosine and its analogs. Drug Discov Today. 2021 Jun;26(6):1490-1500.

物理化学性质

• 密度: 2.12g/cm3
• 沸点: 723.5ºC at 760mmHg
• 分子式: C₁₀H₁₄N₆O₄
• 分子量: 282.26
• 闪点: 391.4ºC
• 精确质量: 282.10800
• PSA: 154.80000
• InChIKey: DGKZTAGCCXJUAT-KQYNXXCUSA-N
• SMILES: NNc1ncnc2c1ncn2C1OC(CO)C(O)C1O

靶点实验

查看更多实验

实验名称：Binding affinity to adenosine A2A receptor in rat striatal membranes by measuring dis... 来源：ChEMBL 靶标：Adenosine receptor A2a External Id：CHEMBL647731

实验名称：Antimalarial activity against drug-sensitive Plasmodium falciparum 3D7 after 24 hrs 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL898384

实验名称：Antimalarial activity against chloroquine,pyrimethamine-resistant Plasmodium falcipar... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL898385

实验名称：Selectivity index, ratio of CC50 for human KB cells to IC50 for Plasmodium falciparum... 来源：ChEMBL 靶标：N/A External Id：CHEMBL898390

实验名称：Antiproliferative activity against human HeLa cells after 72 hrs by MTS assay 来源：ChEMBL 靶标：HeLa External Id：CHEMBL1775980

实验名称：Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) after 24 hrs by fl... 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL4689557

实验名称：Displacement of FITC-geldanamycin from GRP94 (unknown origin) after 24 hrs by fluores... 来源：ChEMBL 靶标：Endoplasmin External Id：CHEMBL4689556

实验名称：Antiproliferative activity against human MCF7 cells after 72 hrs by MTS assay 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL1775982

实验名称：Antimalarial activity against chloroquine, pyrimethamine and cycloguanil-resistant Pl... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL898386

实验名称：Displacement of FITC-geldanamycin from HSP90alpha (unknown origin) at 50 uM after 24 ... 来源：ChEMBL 靶标：Heat shock protein HSP 90-alpha External Id：CHEMBL4689559

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英文别名

• 7-benzyl-6-hydrazino-7H-purine
• 6-Hydrazino-7-benzyl-7H-purin
• N6-hydrazinoadenosine
• 7-benzyl-6-hydrazinyl-7h-purine
• N6-aminoadenosine