碘克沙酸

• 常用名: 碘克沙酸
• 英文名: ioxaglic acid
• CAS号: 59017-64-0
• 分子量: 1268.88000
• 密度: 2.545g/cm3
• 沸点: 887.9ºC at 760 mmHg
• 分子式: C₂₄H₂₁I₆N₅O₈
• 熔点: 302°C
• 闪点: 490.8ºC

碘克沙酸用途

Ioxaglic acid(P-286)是带负电的造影剂,可用作计算机断层扫描(CT)中使用的糖胺聚糖(GAG)的反向指示剂。通过定量评估糖胺聚糖含量[1][2],Ioxaglic可用于人类骨关节炎软骨的成像。

碘克沙酸名称

• 中文名: 碘克沙酸
• 英文名: ioxaglic acid

碘克沙酸生物活性

• 描述: Ioxaglic acid(P-286)是带负电的造影剂,可用作计算机断层扫描(CT)中使用的糖胺聚糖(GAG)的反向指示剂。通过定量评估糖胺聚糖含量[1][2],Ioxaglic可用于人类骨关节炎软骨的成像。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体内研究: Ioxaglic酸对软骨中观察到的GAG梯度敏感,并且能够测量类似的GAG浓度[2]。
• 参考文献:

  [1]. Gonsette RE, et, al. New contrast media in cerebral angiography: animal experiments and preliminary clinical studies. Invest Radiol. Nov-Dec 1980;15(6 Suppl):S270-4.

  [2]. Baer K, et, al. Spectral CT imaging of human osteoarthritic cartilage via quantitative assessment of glycosaminoglycan content using multiple contrast agents. APL Bioeng. 2021 Apr 1;5(2):026101.

碘克沙酸物理化学性质

• 密度: 2.545g/cm3
• 沸点: 887.9ºC at 760 mmHg
• 熔点: 302°C
• 分子式: C₂₄H₂₁I₆N₅O₈
• 分子量: 1268.88000
• 闪点: 490.8ºC
• 精确质量: 1268.57000
• PSA: 194.24000
• LogP: 4.69100
• InChIKey: TYYBFXNZMFNZJT-UHFFFAOYSA-N
• SMILES: CNC(=O)c1c(I)c(C(=O)NCC(=O)Nc2c(I)c(C(=O)O)c(I)c(C(=O)NCCO)c2I)c(I)c(N(C)C(C)=O)c1I
• 折射率: 1.786
• 水溶解性: Very slightly soluble in water, slightly soluble in ethanol (96 per cent), very slightly soluble in methylene chloride. It dissolves in dilute solutions of alkali hydroxides.

碘克沙酸毒性和生态

碘克沙酸安全信息

• 危险品运输编码: NONH for all modes of transport

碘克沙酸靶点实验

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碘克沙酸英文别名

• Ioxaglic acid
• 3-[[2-[[3-[acetyl(methyl)amino]-2,4,6-triiodo-5-(methylcarbamoyl)benzoyl]amino]acetyl]amino]-5-(2-hydroxyethylcarbamoyl)-2,4,6-triiodobenzoic acid