4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[(1-methylpiperidin-4-yl)oxy]quinazoline

• 常用名: 4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[(1-methylpiperidin-4-yl)oxy]quinazoline
• 英文名: 4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[(1-methylpiperidin-4-yl)oxy]quinazoline
• CAS号: 612500-80-8
• 分子量: 416.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₁H₂₂ClFN₄O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 4-(3-Chloro-2-fluoroanilino)-7-methoxy-6-[(1-methylpiperidin-4-yl)oxy]quinazoline

物理化学性质

• 分子式: C₂₁H₂₂ClFN₄O₂
• 分子量: 416.9
• InChIKey: PUGRPTFZBHHZPM-UHFFFAOYSA-N
• SMILES: COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC1CCN(C)CC1

靶点实验

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实验名称：Inhibition of EGFR 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL856356

实验名称：Volume of distribution in Wistar rat at 2 mg/kg, iv and 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL856369

实验名称：AUC in Wistar rat at 5 mg/kg, po normalized to 1 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL856372

实验名称：Antiproliferative activity against EGF-stimulated KB cells 来源：ChEMBL 靶标：Epidermal growth factor receptor External Id：CHEMBL856357

实验名称：Aqueous solubility at pH 7.4 来源：ChEMBL 靶标：N/A External Id：CHEMBL855372

实验名称：Free drug level in rat plasma at 37 degC 来源：ChEMBL 靶标：Plasma External Id：CHEMBL855373

实验名称：Dissociation constant, pKa of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL856366

实验名称：Bioavailability in Wistar rat at 2 mg/kg, iv and 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL856367

实验名称：Clearance in Wistar rat at 2 mg/kg, iv and 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL856368

实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301363

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