6-{[1-(Carbamoylmethyl)piperidin-4-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline

• 常用名: 6-{[1-(Carbamoylmethyl)piperidin-4-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline
• 英文名: 6-{[1-(Carbamoylmethyl)piperidin-4-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline
• CAS号: 612500-87-5
• 分子量: 459.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₂H₂₃ClFN₅O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 6-{[1-(Carbamoylmethyl)piperidin-4-yl]oxy}-4-(3-chloro-2-fluoroanilino)-7-methoxyquinazoline

物理化学性质

• 分子式: C₂₂H₂₃ClFN₅O₃
• 分子量: 459.9
• InChIKey: DIBGTMXGHUALIU-UHFFFAOYSA-N
• SMILES: COc1cc2ncnc(Nc3cccc(Cl)c3F)c2cc1OC1CCN(CC(N)=O)CC1

靶点实验

查看更多实验

实验名称：Volume of distribution in Wistar rat at 2 mg/kg, iv and 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL856369

实验名称：AUC in Wistar rat at 5 mg/kg, po normalized to 1 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL856372

实验名称：Free drug level in rat plasma in 25 degC 来源：ChEMBL 靶标：Plasma External Id：CHEMBL856373

实验名称：Inhibition of full-length HER2 phosphorylation transfected in in human MCF-7 cl.24 ce... 来源：ChEMBL 靶标：Receptor tyrosine-protein kinase erbB-2 External Id：CHEMBL2412609

实验名称：Dissociation constant, pKa of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL856366

实验名称：Bioavailability in Wistar rat at 2 mg/kg, iv and 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL856367

实验名称：Clearance in Wistar rat at 2 mg/kg, iv and 5 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL856368

实验名称：ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301363

实验名称：ASTRAZENECA: Solubility in pH7.4 buffer using solid starting material using the metho... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3301364

实验名称：Fraction unbound in human plasma 来源：ChEMBL 靶标：Plasma External Id：CHEMBL2412593

共14条，当前第1页，共2页

1

2