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(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide

更新时间：2025-08-21 22:43:25

(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide结构式
(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide结构式
品牌特惠专场 		常用名 (2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide 英文名 (2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide
CAS号 625114-41-2 分子量 421.89800
密度 N/A 沸点 N/A
分子式 C19H20ClN3O4S 熔点 N/A
MSDS N/A 闪点 N/A

 用途


Piragliatin (RO 4389620.

 名称

英文名 (2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide
英文别名 更多

 物理化学性质

分子式 C19H20ClN3O4S
分子量 421.89800
精确质量 421.08600
PSA 117.96000
LogP 4.74540
InChIKey XEANIURBPHCHMG-SWLSCSKDSA-N
SMILES CS(=O)(=O)c1ccc(C(CC2CCC(=O)C2)C(=O)Nc2cnccn2)cc1Cl

 合成线路

氨基吡嗪结构式

氨基吡嗪

5049-61-6

(R)-2-(3-chloro-4-methanesulfonyl-phenyl)-3-((R)-3-oxo-cyclopentyl)-propionyl chloride结构式

(R)-2-(3-chloro...

1003013-93-1

~%

(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide结构式

(2R)-2-(3-chlor...

625114-41-2

文献：Daniewski, Andrzej Robert; Liu, Wen; Radinov, Roumen Nikolaev Patent: US2007/244129 A1, 2007 ; Location in patent: Page/Page column 5; 7; 10 ; US 20070244129 A1
氨基吡嗪结构式

氨基吡嗪

5049-61-6

(2R)-2-(3-chloro-4-methanesulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]propanoic acid结构式

(2R)-2-(3-chlor...

625114-43-4

~44%

(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide结构式

(2R)-2-(3-chlor...

625114-41-2

文献：Sarabu, Ramakanth; Bizzarro, Fred T.; Corbett, Wendy L.; Dvorozniak, Mark T.; Geng, Wanping; Grippo, Joseph F.; Haynes, Nancy-Ellen; Hutchings, Stanley; Garofalo, Lisa; Guertin, Kevin R.; Hilliard, Darryl W.; Kabat, Marek; Kester, Robert F.; Ka, Wang; Liang, Zhenmin; Mahaney, Paige E.; Marcus, Linda; Matschinsky, Franz M.; Moore, David; Racha, Jagdish; Radinov, Roumen; Ren, Yi; Qi, Lida; Pignatello, Michael; Spence, Cheryl L.; Steele, Thomas; Tengi, John; Grimsby, Joseph Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7021 - 7036
2-氯茴香硫醚结构式

2-氯茴香硫醚

17733-22-1

~%

(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide结构式

(2R)-2-(3-chlor...

625114-41-2

文献：Sarabu, Ramakanth; Bizzarro, Fred T.; Corbett, Wendy L.; Dvorozniak, Mark T.; Geng, Wanping; Grippo, Joseph F.; Haynes, Nancy-Ellen; Hutchings, Stanley; Garofalo, Lisa; Guertin, Kevin R.; Hilliard, Darryl W.; Kabat, Marek; Kester, Robert F.; Ka, Wang; Liang, Zhenmin; Mahaney, Paige E.; Marcus, Linda; Matschinsky, Franz M.; Moore, David; Racha, Jagdish; Radinov, Roumen; Ren, Yi; Qi, Lida; Pignatello, Michael; Spence, Cheryl L.; Steele, Thomas; Tengi, John; Grimsby, Joseph Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7021 - 7036
2-环戊烯酮结构式

2-环戊烯酮

930-30-3

~%

(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide结构式

(2R)-2-(3-chlor...

625114-41-2

文献：Sarabu, Ramakanth; Bizzarro, Fred T.; Corbett, Wendy L.; Dvorozniak, Mark T.; Geng, Wanping; Grippo, Joseph F.; Haynes, Nancy-Ellen; Hutchings, Stanley; Garofalo, Lisa; Guertin, Kevin R.; Hilliard, Darryl W.; Kabat, Marek; Kester, Robert F.; Ka, Wang; Liang, Zhenmin; Mahaney, Paige E.; Marcus, Linda; Matschinsky, Franz M.; Moore, David; Racha, Jagdish; Radinov, Roumen; Ren, Yi; Qi, Lida; Pignatello, Michael; Spence, Cheryl L.; Steele, Thomas; Tengi, John; Grimsby, Joseph Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7021 - 7036
(3-chloro-4-methylsulfanyl-phenyl)-oxo-acetic acid methyl ester结构式

(3-chloro-4-met...

393165-02-1

~%

(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide结构式

(2R)-2-(3-chlor...

625114-41-2

文献：Sarabu, Ramakanth; Bizzarro, Fred T.; Corbett, Wendy L.; Dvorozniak, Mark T.; Geng, Wanping; Grippo, Joseph F.; Haynes, Nancy-Ellen; Hutchings, Stanley; Garofalo, Lisa; Guertin, Kevin R.; Hilliard, Darryl W.; Kabat, Marek; Kester, Robert F.; Ka, Wang; Liang, Zhenmin; Mahaney, Paige E.; Marcus, Linda; Matschinsky, Franz M.; Moore, David; Racha, Jagdish; Radinov, Roumen; Ren, Yi; Qi, Lida; Pignatello, Michael; Spence, Cheryl L.; Steele, Thomas; Tengi, John; Grimsby, Joseph Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7021 - 7036
未登录结构式

未登录

625827-26-1

~%

(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide结构式

(2R)-2-(3-chlor...

625114-41-2

文献：Sarabu, Ramakanth; Bizzarro, Fred T.; Corbett, Wendy L.; Dvorozniak, Mark T.; Geng, Wanping; Grippo, Joseph F.; Haynes, Nancy-Ellen; Hutchings, Stanley; Garofalo, Lisa; Guertin, Kevin R.; Hilliard, Darryl W.; Kabat, Marek; Kester, Robert F.; Ka, Wang; Liang, Zhenmin; Mahaney, Paige E.; Marcus, Linda; Matschinsky, Franz M.; Moore, David; Racha, Jagdish; Radinov, Roumen; Ren, Yi; Qi, Lida; Pignatello, Michael; Spence, Cheryl L.; Steele, Thomas; Tengi, John; Grimsby, Joseph Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7021 - 7036
未登录结构式

未登录

625826-94-0

~%

(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide结构式

(2R)-2-(3-chlor...

625114-41-2

文献：Sarabu, Ramakanth; Bizzarro, Fred T.; Corbett, Wendy L.; Dvorozniak, Mark T.; Geng, Wanping; Grippo, Joseph F.; Haynes, Nancy-Ellen; Hutchings, Stanley; Garofalo, Lisa; Guertin, Kevin R.; Hilliard, Darryl W.; Kabat, Marek; Kester, Robert F.; Ka, Wang; Liang, Zhenmin; Mahaney, Paige E.; Marcus, Linda; Matschinsky, Franz M.; Moore, David; Racha, Jagdish; Radinov, Roumen; Ren, Yi; Qi, Lida; Pignatello, Michael; Spence, Cheryl L.; Steele, Thomas; Tengi, John; Grimsby, Joseph Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7021 - 7036
3-氯-4-甲硫基苯乙酸结构式

3-氯-4-甲硫基苯乙酸

87776-75-8

~%

(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide结构式

(2R)-2-(3-chlor...

625114-41-2

文献：Sarabu, Ramakanth; Bizzarro, Fred T.; Corbett, Wendy L.; Dvorozniak, Mark T.; Geng, Wanping; Grippo, Joseph F.; Haynes, Nancy-Ellen; Hutchings, Stanley; Garofalo, Lisa; Guertin, Kevin R.; Hilliard, Darryl W.; Kabat, Marek; Kester, Robert F.; Ka, Wang; Liang, Zhenmin; Mahaney, Paige E.; Marcus, Linda; Matschinsky, Franz M.; Moore, David; Racha, Jagdish; Radinov, Roumen; Ren, Yi; Qi, Lida; Pignatello, Michael; Spence, Cheryl L.; Steele, Thomas; Tengi, John; Grimsby, Joseph Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7021 - 7036
(3-chloro-4-methylsulfanyl-phenyl)-N-[2(R)-hydroxy-1(R)-methyl-2(R)-phenyl-ethyl]-N-methyl acetamide结构式

(3-chloro-4-met...

588940-69-6

~%

(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide结构式

(2R)-2-(3-chlor...

625114-41-2

文献：Sarabu, Ramakanth; Bizzarro, Fred T.; Corbett, Wendy L.; Dvorozniak, Mark T.; Geng, Wanping; Grippo, Joseph F.; Haynes, Nancy-Ellen; Hutchings, Stanley; Garofalo, Lisa; Guertin, Kevin R.; Hilliard, Darryl W.; Kabat, Marek; Kester, Robert F.; Ka, Wang; Liang, Zhenmin; Mahaney, Paige E.; Marcus, Linda; Matschinsky, Franz M.; Moore, David; Racha, Jagdish; Radinov, Roumen; Ren, Yi; Qi, Lida; Pignatello, Michael; Spence, Cheryl L.; Steele, Thomas; Tengi, John; Grimsby, Joseph Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7021 - 7036

 靶点实验

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External Id：CHEMBL1788085
实验名称：Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometry...
来源：ChEMBL
靶标：Hexokinase-4
External Id：CHEMBL1788086
实验名称：Activation of rat glucokinase
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靶标：Hexokinase-4
External Id：CHEMBL3223667
实验名称：p53 small molecule agonists, cell-based qHTS assay: qHTS cell viability counter scree...
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靶标：N/A
External Id：P53600
实验名称：Activation of recombinant human glucokinase assessed as formation of glucose-6-phosph...
来源：ChEMBL
靶标：Hexokinase-4
External Id：CHEMBL3223666
实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: qHTS ce...
来源：824
靶标：N/A
External Id：P53MS958
实验名称：p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes: Summary
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External Id：P53MS482
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External Id：P53344
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靶标：tumor suppressor p53 [Homo sapiens]
External Id：P53MS233
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 英文别名

Piragliatin
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CAS号[625114-41-2]化源网提供[(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide]MSDS、说明、性质、英文名、生产厂家、作用/用途、分子量、密度、沸点、熔点、结构式等。>>移动MIP版：(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide
标题：625114-41-2_CAS号:625114-41-2_(2R)-2-(3-chloro-4-methylsulfonylphenyl)-3-[(1R)-3-oxocyclopentyl]-N-pyrazin-2-ylpropanamide - 化源网 地址：https://m.chemsrc.com/cas/625114-41-2_1043406.html

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