4-(2-甲基-1-吡咯烷基)-7-氯喹啉

• 常用名: 4-(2-甲基-1-吡咯烷基)-7-氯喹啉
• 英文名: Hydroxychloroquine Impurity F
• CAS号: 6281-58-9
• 分子量: 246.73500
• 密度: 1.214g/cm3
• 沸点: 392.5ºC at 760 mmHg
• 分子式: C₁₄H₁₅ClN₂
• 熔点: N/A
• 闪点: 191.2ºC

4-(2-甲基-1-吡咯烷基)-7-氯喹啉用途

Hydroxychloroquine Impurity F 是 Hydroxychloroquine 的杂质。Hydroxychloroquine 是一种合成的抗疟疾剂,也可以抑制 Toll 样受体 7/9 (TLR7/9) 信号传导。Hydroxychloroquine 有效抑制 SARS-CoV-2 感染[1][2][3]。

4-(2-甲基-1-吡咯烷基)-7-氯喹啉名称

• 中文名: 4-(2-甲基-1-吡咯烷基)-7-氯喹啉
• 英文名: 7-chloro-4-(2-methylpyrrolidin-1-yl)quinoline

4-(2-甲基-1-吡咯烷基)-7-氯喹啉生物活性

• 描述: Hydroxychloroquine Impurity F 是 Hydroxychloroquine 的杂质。Hydroxychloroquine 是一种合成的抗疟疾剂,也可以抑制 Toll 样受体 7/9 (TLR7/9) 信号传导。Hydroxychloroquine 有效抑制 SARS-CoV-2 感染[1][2][3]。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Manzo C, et al. Psychomotor Agitation Following Treatment with Hydroxychloroquine. Drug Saf Case Rep. 2017 Dec;4(1):6.

  [2]. Lamphier M, et al. Novel small molecule inhibitors of TLR7 and TLR9: mechanism of action and efficacy in vivo. Mol Pharmacol. 2014 Mar;85(3):429-40.

  [3]. Yao X, et al. In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020 Mar 9. pii: ciaa237.

4-(2-甲基-1-吡咯烷基)-7-氯喹啉物理化学性质

• 密度: 1.214g/cm3
• 沸点: 392.5ºC at 760 mmHg
• 分子式: C₁₄H₁₅ClN₂
• 分子量: 246.73500
• 闪点: 191.2ºC
• 精确质量: 246.09200
• PSA: 16.13000
• LogP: 3.94190
• InChIKey: GYORBDCAYLXAIL-UHFFFAOYSA-N
• SMILES: CC1CCCN1c1ccnc2cc(Cl)ccc12
• 折射率: 1.626
• 储存条件: -20°C

4-(2-甲基-1-吡咯烷基)-7-氯喹啉毒性和生态

4-(2-甲基-1-吡咯烷基)-7-氯喹啉靶点实验

查看更多实验

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Bas... 来源：Broad Institute 靶标：N/A External Id：2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：High throughput screen for small molecule inhibitors of a hypoxia-regulated fluoresce... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1149-MLP

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Prima... 来源：NCGC 靶标：apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] External Id：AMA1100

共89条，当前第1页，共9页

1

2

3

4

5

4-(2-甲基-1-吡咯烷基)-7-氯喹啉英文别名

• nx 357
• 4-(2-Methyl-1-Pyrrolidyl)-7-Chloroquinoline
• Plaquenil Impurity 2