tert-butyl N-[(1S)-1-[(2S,4R)-2-[[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinyl-cyclopropyl]carbamoyl]-4-[(4,6-dimethoxy-1-isoquinolyl)oxy]pyrrolidine-1-carbonyl]-2,2-dimethyl-propyl]carbamate

• 常用名: tert-butyl N-[(1S)-1-[(2S,4R)-2-[[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinyl-cyclopropyl]carbamoyl]-4-[(4,6-dimethoxy-1-isoquinolyl)oxy]pyrrolidine-1-carbonyl]-2,2-dimethyl-propyl]carbamate
• 英文名: tert-butyl N-[(1S)-1-[(2S,4R)-2-[[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinyl-cyclopropyl]carbamoyl]-4-[(4,6-dimethoxy-1-isoquinolyl)oxy]pyrrolidine-1-carbonyl]-2,2-dimethyl-propyl]carbamate
• CAS号: 630420-18-7
• 分子量: 743.9
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₆H₄₉N₅O₁₀S
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: tert-butyl N-[(1S)-1-[(2S,4R)-2-[[(1R,2S)-1-(cyclopropylsulfonylcarbamoyl)-2-vinyl-cyclopropyl]carbamoyl]-4-[(4,6-dimethoxy-1-isoquinolyl)oxy]pyrrolidine-1-carbonyl]-2,2-dimethyl-propyl]carbamate

物理化学性质

• 分子式: C₃₆H₄₉N₅O₁₀S
• 分子量: 743.9
• InChIKey: NMXBGPWAXNOKMF-MRDPMNOASA-N
• SMILES: C=CC1CC1(NC(=O)C1CC(Oc2ncc(OC)c3cc(OC)ccc23)CN1C(=O)C(NC(=O)OC(C)(C)C)C(C)(C)C)C(=O)NS(=O)(=O)C1CC1

靶点实验

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实验名称：Apparent terminal half life in Sprague-Dawley rat at 5 mg/kg, iv by LC/MS/MS analysis 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3128368

实验名称：Cytotoxicity against human HuH7 cells 来源：ChEMBL 靶标：Huh-7 External Id：CHEMBL3129077

实验名称：Whole body plasma clearance in Sprague-Dawley rat at 5 mg/kg, iv by LC/MS/MS analysis 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3128369

实验名称：Oral bioavailability in Sprague-Dawley rat at 15 mg/kg administered via gavage by LC/... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3129078

实验名称：AUC in Sprague-Dawley rat at 15 mg/kg, po administered via gavage by LC/MS/MS analysi... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3129079

实验名称：Antiviral activity against Hepatitis C virus genotype 1b Con1 after 4 days by cell-ba... 来源：ChEMBL 靶标：Hepacivirus hominis External Id：CHEMBL3128634

实验名称：Inhibition of Hepatitis C virus genotype 1a H77 recombinant NS3/4A protease expressed... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3128635

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