盐酸地匹福林

• 常用名: 盐酸地匹福林
• 英文名: Dipivefrin HCl
• CAS号: 64019-93-8
• 分子量: 387.89800
• 密度: N/A
• 沸点: 473.7ºC at 760 mmHg
• 分子式: C₁₉H₃₀ClNO₅
• 熔点: 158-159°
• 闪点: 240.3ºC

盐酸地匹福林用途

Dipivefrin hydrochloride (Dipivefrine hydrochloride) 是一种抗青光眼前体药物,通过角膜中的酯酶水解为其活性化合物肾上腺素。

盐酸地匹福林名称

• 中文名: 盐酸地匹福林
• 英文名: dipivefrin hydrochloride
• 中文别名: 4-(1-羟基-2-(甲基氨基)乙基)-1,2-苯二醇二特戊酸酯盐酸盐

盐酸地匹福林生物活性

• 描述: Dipivefrin hydrochloride (Dipivefrine hydrochloride) 是一种抗青光眼前体药物,通过角膜中的酯酶水解为其活性化合物肾上腺素。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 神经疾病
• 体内研究: 盐酸二吡氟林(0.3-10μg/kg；i.p.；)诱导记忆增强涉及中枢β-而不是α肾上腺素能机制[3]。动物模型：雄性60日龄CFW小鼠(23-28g)[3]剂量：0.3μg/kg、1.0μg/kg、3.0μg/kg、10μg/kg；腹腔注射；训练后结果：抑制回避和Y迷宫辨别任务的保留率均显著提高,且呈剂量依赖性。
• 参考文献:

  [1]. Edgar DF, et al. Effects of dipivefrin and pilocarpine on pupil diameter, automated perimetry and LogMAR acuity. Graefes Arch Clin Exp Ophthalmol. 1999 Feb;237(2):117-24.

  [2]. Anderson JA, et al. Effects of echothiophate on enzymatic hydrolysis of dipivefrin. Arch Ophthalmol. 1984 Jun;102(6):913-6.

  [3]. Introini-Collison I, et al. Memory-enhancing effects of post-training dipivefrin and epinephrine: involvement of peripheral and central adrenergic receptors. Brain Res. 1992 Feb 14;572(1-2):81-6.

盐酸地匹福林物理化学性质

• 沸点: 473.7ºC at 760 mmHg
• 熔点: 158-159°
• 分子式: C₁₉H₃₀ClNO₅
• 分子量: 387.89800
• 闪点: 240.3ºC
• 精确质量: 387.18100
• PSA: 84.86000
• LogP: 4.03530
• InChIKey: VKFAUCPBMAGVRG-UHFFFAOYSA-N
• SMILES: CNCC(O)c1ccc(OC(=O)C(C)(C)C)c(OC(=O)C(C)(C)C)c1.Cl
• 储存条件: -20°C， 充氩
• 水溶解性: Freely soluble in water, very soluble in methanol, freely soluble in ethanol (96 per cent) and in methylene chloride.

盐酸地匹福林毒性和生态

盐酸地匹福林安全信息

• 危险品运输编码: UN 2811 6.1 / PGIII

盐酸地匹福林靶点实验

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盐酸地匹福林英文别名

• Dipivefrin HCL
• EINECS 264-609-5
• AKPro
• Dipivefrin hydrochloride
• [2-(2,2-dimethylpropanoyloxy)-4-[1-hydroxy-2-(methylamino)ethyl]phenyl] 2,2-dimethylpropanoate,hydrochloride
• (1)-4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylene dipivalate hydrochloride
• Dipivalyl epinephrine hydrochloride
• Dipivefrine hydrochloride