1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-6-pyrrolo[2,1-f][1,2,4]triazinyl]oxy]-2-propanol

• 常用名: 1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-6-pyrrolo[2,1-f][1,2,4]triazinyl]oxy]-2-propanol
• 英文名: 1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-6-pyrrolo[2,1-f][1,2,4]triazinyl]oxy]-2-propanol
• CAS号: 649735-47-7
• 分子量: 370.4
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₉FN₄O₃
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 1-[[4-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methyl-6-pyrrolo[2,1-f][1,2,4]triazinyl]oxy]-2-propanol

物理化学性质

• 分子式: C₁₉H₁₉FN₄O₃
• 分子量: 370.4
• InChIKey: WCWUXEGQKLTGDX-NSHDSACASA-N
• SMILES: Cc1cc2c(F)c(Oc3ncnn4cc(OCC(C)O)c(C)c34)ccc2[nH]1

靶点实验

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实验名称：Drug level in monkey liver cytosol assessed as compound formation treated with 2 uM [... 来源：ChEMBL 靶标：N/A External Id：CHEMBL3534820

实验名称：Drug level in human liver cytosol assessed as compound formation treated with 2 uM [1... 来源：ChEMBL 靶标：Liver cytosol External Id：CHEMBL3534821

实验名称：Drug level in rat liver cytosol assessed as compound formation treated with 2 uM [14C... 来源：ChEMBL 靶标：Liver cytosol External Id：CHEMBL3534819

实验名称：AUC in mice at 50 mg/kg after 4 hrs 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL859787

实验名称：Drug level in human liver microsomes assessed as compound formation treated with 2 uM... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3534824

实验名称：Drug metabolism in human liver microsomes assessed as (R)-1-(4-(4-fluoro-2-methyl-1H-... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3531904

实验名称：Cmax in mice at 50 mg/kg after 4 hrs 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL859788

实验名称：Inhibitory activity against CYP3A4 来源：ChEMBL 靶标：Cytochrome P450 3A4 External Id：CHEMBL859789

实验名称：Drug level in rat liver microsomes assessed as compound formation treated with 2 uM [... 来源：ChEMBL 靶标：Liver microsome External Id：CHEMBL3534822

实验名称：Inhibitory activity against hERG by patch-clamp assay 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL859790

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