N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-4-pyrimidinyl]-4-morpholinesulfonamide

• 常用名: N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-4-pyrimidinyl]-4-morpholinesulfonamide
• 英文名: N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-4-pyrimidinyl]-4-morpholinesulfonamide
• CAS号: 654074-09-6
• 分子量: 475.5
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₈H₂₃F₂N₅O₄S₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: N-[2-[[(2,3-Difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-4-pyrimidinyl]-4-morpholinesulfonamide

物理化学性质

• 分子式: C₁₈H₂₃F₂N₅O₄S₂
• 分子量: 475.5
• InChIKey: CWSXHDBZSCOEHO-GFCCVEGCSA-N
• SMILES: CC(CO)Nc1cc(NS(=O)(=O)N2CCOCC2)nc(SCc2cccc(F)c2F)n1

靶点实验

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实验名称：Volume of distribution at steady state in iv dosed rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3404727

实验名称：Half life in iv dosed rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3404728

实验名称：Fraction of the dose absorbed in iv dosed rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3404725

实验名称：Clearance in iv dosed rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3404726

实验名称：Dose normalized AUC in po dosed rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3404729

实验名称：Fraction unbound in human plasma by equilibrium dialysis method 来源：ChEMBL 靶标：Plasma External Id：CHEMBL3404719

实验名称：Lipophilicity, log D of the compound by shake flask technique 来源：ChEMBL 靶标：N/A External Id：CHEMBL3404720

实验名称：Apparent permeability from apical to basolateral side in human Caco2 cells 来源：ChEMBL 靶标：N/A External Id：CHEMBL3404723

实验名称：Bioavailability in iv dosed rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL3404724

实验名称：Intrinsic clearance in human hepatocytes assessed per 10'6 cells 来源：ChEMBL 靶标：Hepatocyte External Id：CHEMBL3404722

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