iKIX1

• 常用名: iKIX1
• 英文名: iKIX1
• CAS号: 656222-54-7
• 分子量: 303.168
• 密度: 1.6±0.1 g/cm3
• 沸点: N/A
• 分子式: C₁₀H₈Cl₂N₄OS
• 熔点: N/A
• 闪点: N/A

iKIX1用途

光滑念珠菌Pdr1激活结构域与光滑念珠菌Gal11A KIX结构域相互作用的小分子抑制剂,Ki为18μM；阻断Gal11/Med15募集并抑制Pdr1依赖性基因激活,并在体外和动物模型中使抗药性光滑念珠菌对唑类抗真菌药重新敏感,用于播散性和泌尿道光滑念珠菌感染；一种新的真菌传染病治疗策略。

iKIX1名称

• 英文名: iKIX1

iKIX1生物活性

• 描述: 光滑念珠菌Pdr1激活结构域与光滑念珠菌Gal11A KIX结构域相互作用的小分子抑制剂,Ki为18μM；阻断Gal11/Med15募集并抑制Pdr1依赖性基因激活,并在体外和动物模型中使抗药性光滑念珠菌对唑类抗真菌药重新敏感,用于播散性和泌尿道光滑念珠菌感染；一种新的真菌传染病治疗策略。
• 参考文献: References 1. Nishikawa JL, et al. Nature. 2016 Feb 25;530(7591):485-9. View Related Products by Target Fungal

iKIX1物理化学性质

• 密度: 1.6±0.1 g/cm3
• 分子式: C₁₀H₈Cl₂N₄OS
• 分子量: 303.168
• 精确质量: 301.979584
• LogP: 2.26
• InChIKey: XKQJVBSDCOCZFV-UHFFFAOYSA-N
• SMILES: N#CCC(=O)NNC(=S)Nc1ccc(Cl)c(Cl)c1
• 折射率: 1.681

iKIX1靶点实验

查看更多实验

实验名称：Aqueous solubility of compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL5323786

实验名称：Inhibition of fluorescent probe FITC tagged PDR1-KIX domain (unknown origin) protein-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5323738

实验名称：Synergistic antifungal activity against fluconazole-resistant Candida glabrata 0161 a... 来源：ChEMBL 靶标：Nakaseomyces glabratus External Id：CHEMBL5323750

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Antifungal activity against fluconazole-resistant Candida glabrata 0161 assessed as f... 来源：ChEMBL 靶标：Nakaseomyces glabratus External Id：CHEMBL5323747

实验名称：Antifungal activity against fluconazole-resistant Candida glabrata 0161 assessed as f... 来源：ChEMBL 靶标：Nakaseomyces glabratus External Id：CHEMBL5323745

实验名称：Antifungal activity against fluconazole-resistant Candida glabrata 0161 assessed as f... 来源：ChEMBL 靶标：Nakaseomyces glabratus External Id：CHEMBL5323746

实验名称：The chemical genetic matrix (CGM) dataset as reported in Wildenhain et al. (2015) Pre... 来源：11924 靶标：N/A External Id：CGM data for Cell Systems paper Dec 2015

实验名称：Antifungal activity against FLC-resistant Candida glabrata 0161 infected in cyclophos... 来源：ChEMBL 靶标：Nakaseomyces glabratus External Id：CHEMBL5323740

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iKIX1英文别名

• 2-(Cyanoacetyl)-N-(3,4-dichlorophenyl)hydrazinecarbothioamide
• 3-[(2-Cyanoacetyl)amino]-1-(3,4-dichlorophenyl)thiourea
• MFCD00119122
• iKIX1
• 2-(2-cyanoacetyl)-N-(3,4-dichlorophenyl)hydrazine-1-carbothioamide
• Acetic acid, 2-cyano-, 2-[[(3,4-dichlorophenyl)amino]thioxomethyl]hydrazide