神经节苷脂GD2,Disialo,人脑

更新时间：2025-08-25 21:03:43

神经节苷脂GD2,Disialo,人脑结构式	常用名	神经节苷脂GD2,Disialo,人脑	英文名	GD2-GANGLIOSIDE
	CAS号	65988-71-8	分子量	1673.921
	密度	1.4±0.1 g/cm3	沸点	1633.3±65.0 °C at 760 mmHg
	分子式	C₇₂H₁₂₆N₄O₃₄	熔点	N/A
	MSDS	美版	闪点	941.6±34.3 °C

中文名	双唾液酸神经节苷脂 GD2
英文名	GD2-GANGLIOSIDE
英文别名	更多

密度	1.4±0.1 g/cm3
沸点	1633.3±65.0 °C at 760 mmHg
分子式	C₇₂H₁₂₆N₄O₃₄
分子量	1673.921
闪点	941.6±34.3 °C
精确质量	1672.903564
LogP	9.76
InChIKey	FFILOTSTFMXQJC-QCFYAKGBSA-N
SMILES	CCCCCCCCCCCCCC=CC(O)C(COC1OC(CO)C(OC2OC(CO)C(OC3OC(CO)C(O)C(O)C3NC(C)=O)C(OC3(C(=O)O)CC(O)C(N)C(C(O)C(O)COC4(C(=O)O)CC(O)C(N)C(C(O)C(O)CO)O4)O3)C2O)C(O)C1O)NC(=O)CCCCCCCCCCCCCCCCC
外观性状	lyophilized powder
蒸汽压	0.0±0.6 mmHg at 25°C
折射率	1.598
储存条件	−20°C

个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport
WGK德国	3

Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Neuron 82(2) , 308-19, (2014)

Soluble Aβ oligomers contribute importantly to synaptotoxicity in Alzheimer's disease, but their dynamics in vivo remain unclear. Here, we found that soluble Aβ oligomers were sequestered from brain i...

Key role for myeloid cells: phase II results of anti-G(D2) antibody 3F8 plus granulocyte-macrophage colony-stimulating factor for chemoresistant osteomedullary neuroblastoma.

Int. J. Cancer 135(9) , 2199-205, (2014)

Anti-G(D2) murine antibody 3F8 plus subcutaneously (sc) administered granulocyte-macrophage colony-stimulating factor (GM-CSF) was used against primary refractory neuroblastoma in metastatic osteomedu...

Fenretinide sensitizes multidrug-resistant human neuroblastoma cells to antibody-independent and ch14.18-mediated NK cell cytotoxicity.

J. Mol. Med. 91(4) , 459-72, (2013)

Neuroblastoma (NB) is the most common extracranial solid tumor in children. Combining passive immunotherapy with an antibody to the disialoganglioside GD2 (ch14.18/SP2/0) and cytokines with 13-cis-ret...

Ganglioside GD2 (d18:1/9Z-18:1)

(2S,3R,4E)-3-Hydroxy-2-[(9Z)-9-octadecenoylamino]-4-octadecen-1-yl 5-acetamido-6-[(1S,2R)-2-({5-acetamido-3,5-dideoxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]-β-L-threo-hex-2-ulopyranonosyl}oxy)-1,3-dihy droxypropyl]-3,5-dideoxy-β-L-threo-hex-2-ulopyranonosyl-(2->3)-[2-acetamido-2-deoxy-β-D-galactopyranosyl-(1->4)]-β-D-galactopyranosyl-(1->4)-β-D-glucopyranoside