1-Methyl-6-(4-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridazinyl)-3,4- dihydro-2(1H)-quinolinone

• 常用名: 1-Methyl-6-(4-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridazinyl)-3,4- dihydro-2(1H)-quinolinone
• 英文名: 1-Methyl-6-(4-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridazinyl)-3,4- dihydro-2(1H)-quinolinone
• CAS号: 70386-06-0
• 分子量: 271.31400
• 密度: 1.34g/cm3
• 沸点: N/A
• 分子式: C₁₅H₁₇N₃O₂
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 1-Methyl-6-(4-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridazinyl)-3,4- dihydro-2(1H)-quinolinone

物理化学性质

• 密度: 1.34g/cm3
• 分子式: C₁₅H₁₇N₃O₂
• 分子量: 271.31400
• 精确质量: 271.13200
• PSA: 65.26000
• LogP: 1.23220
• InChIKey: JHPWSIOCWUJGJE-UHFFFAOYSA-N
• SMILES: CC1CC(=O)NN=C1c1ccc2c(c1)CCC(=O)N2C
• 折射率: 1.671

靶点实验

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实验名称：Percent inhibition of low Km cyclic cAMP phosphodiesterase PDE III of guinea pig vent... 来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase B External Id：CHEMBL762674

实验名称：Inhibition of canine cardiac Phosphodiesterase 3 来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase B External Id：CHEMBL764842

实验名称：Evaluated for percent increase in heart rate in anesthetized dogs 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL670348

实验名称：Percent inhibition of cyclic GMP sensitive phosphodiesterase PDE 2 of guinea pig vent... 来源：ChEMBL 靶标：cGMP-dependent 3',5'-cyclic phosphodiesterase External Id：CHEMBL759848

实验名称：Evaluated for percent decrease in maximum arterial blood pressure in anesthetized dog... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL672610

实验名称：Compound was tested for cardiovascular profile in conscious dogs at dose of 500 ug/kg... 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL671173

实验名称：Inhibition of cAMP PDE III enzyme 来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase B External Id：CHEMBL759160

实验名称：Percent inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of guinea... 来源：ChEMBL 靶标：Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B External Id：CHEMBL760753

实验名称：Inhibition of human recombinant PDE3 expressed in Escherichia coli 来源：ChEMBL 靶标：cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B External Id：CHEMBL5256543

实验名称：50% increase in cardiac force in dog by intravenous dose 来源：ChEMBL 靶标：Canis lupus familiaris External Id：CHEMBL822138

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