盐酸多沙普仑

• 常用名: 盐酸多沙普仑
• 英文名: Doxapram (hydrochloride hydrate)
• CAS号: 7081-53-0
• 分子量: 432.983
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₄H₃₃ClN₂O₃
• 熔点: 217-219°
• 闪点: N/A
• 符号: GHS06
• 信号词: Danger

盐酸多沙普仑用途

Doxapram能抑制TASK-1,TASK-3和TASK-1/TASK-3异二聚体通道,EC50分别为410 nM,37 μM和9 μM。

盐酸多沙普仑名称

• 中文名: 盐酸多沙普仑
• 英文名: doxapram hydrochloride monohydrate
• 中文别名: 1-乙基-3,3-二苯基-4-[2-(4-吗啉基)乙基]-2-吡咯烷酮盐酸盐一水合物 | 香草醛.香兰素

盐酸多沙普仑生物活性

• 描述: Doxapram能抑制TASK-1,TASK-3和TASK-1/TASK-3异二聚体通道,EC50分别为410 nM,37 μM和9 μM。
• 相关类别:
  信号通路 >> 跨膜转运 >> 钾通道
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Cotten JF, et al. The ventilatory stimulant doxapram inhibits TASK tandem pore (K2P) potassium channel function but does not affect minimum alveolar anesthetic concentration. Anesth Analg, 2006, 102(3), 779-785.

  [2]. Anderson-Beck, R., et al., Doxapram stimulates dopamine release from the intact rat carotid body in vitro. Neurosci Lett, 1995. 187(1): p. 25-8.

  [3]. Peers, C., Effects of doxapram on ionic currents recorded in isolated type I cells of the neonatal rat carotid body. Brain Res, 1991. 568(1-2): p. 116-22.

盐酸多沙普仑物理化学性质

• 熔点: 217-219°
• 分子式: C₂₄H₃₃ClN₂O₃
• 分子量: 432.983
• 精确质量: 432.217957
• PSA: 42.01000
• LogP: 3.78680
• 储存条件: 室温，干燥
• 水溶解性: Soluble in water, in alcohol and in methylene chloride.

盐酸多沙普仑毒性和生态

盐酸多沙普仑安全信息

• 符号: GHS06
• 信号词: Danger
• 危害声明: H301
• 警示性声明: Missing Phrase - N15.00950417
• 危险品运输编码: UN 2811 6.1 / PGIII

盐酸多沙普仑英文别名

• 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone monohydrochloride monohydrate
• UNII:P5RU6UOQ5Y
• Doxapram hydrochloride monohydrate
• Dopram
• Doxapram HCL
• Stimulexin
• Doxapram monohydrochloride monohydrate
• AHR 619
• Doxapram Hydrochloride hydrate
• 1-Ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate
• Dopram (TN)
• 2-Pyrrolidinone, 1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-, hydrochloride, hydrate (1:1:1)
• 1-Ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one hydrochloride hydrate
• Doxapram Hydrochloride
• 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one,hydrate,hydrochloride
• 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate
• Doxapram HCl H2O
• Doxapram (hydrochloride hydrate)