NSC45586 free base

• 常用名: NSC45586 free base
• 英文名: NSC45586 free base
• CAS号: 739301-85-0
• 分子量: 390.403
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₀H₁₈N₆O₃
• 熔点: N/A
• 闪点: N/A

NSC45586 free base用途

NSC45586游离碱基(NCS 45586,NCI45586)是一种有效的特异性PHLPP2抑制剂,IC50为4μm,靶向PHLPP2 PP2C结构域,抑制MYC并触发细胞死亡。

NSC45586 free base名称

• 英文名: NSC45586 free base

NSC45586 free base生物活性

• 描述: NSC45586游离碱基(NCS 45586,NCI45586)是一种有效的特异性PHLPP2抑制剂,IC50为4μm,靶向PHLPP2 PP2C结构域,抑制MYC并触发细胞死亡。
• 参考文献: 1. Nowak DG, et al. J Cell Biol. 2019 May 15. pii: jcb.201902048. doi: 10.1083/jcb.201902048.

NSC45586 free base物理化学性质

• 分子式: C₂₀H₁₈N₆O₃
• 分子量: 390.403
• InChIKey: LNPJMIMLAFXLSJ-UHFFFAOYSA-N
• SMILES: Cc1cc(N=Nc2ccc(N=Nc3ccc(O)c(C(=O)O)c3)cc2)c(N)cc1N

NSC45586 free base靶点实验

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实验名称：Inhibition of PHLPP in human HT20 cells assessed as increase of phosphorylation of Ak... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1275002

实验名称：Cytoprotective activity against etoposide-induced cell death in african green monkey ... 来源：ChEMBL 靶标：COS-7 External Id：CHEMBL1275119

实验名称：Inhibition of PHLPP expressed in 24 hrs serum starved Cos7 cells assessed as increase... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1275008

实验名称：Inhibition of PHLPP in human HT20 cells assessed as increase of phosphorylation of Fo... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1274996

实验名称：Inhibition of PHLPP in human HT20 cells assessed as increase of phosphorylation of GS... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1274997

实验名称：Inhibition of PHLPP2 phosphatase domain expressed in Escherichia coli 来源：ChEMBL 靶标：PH domain leucine-rich repeat-containing protein phosphatase 2 External Id：CHEMBL1275001

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