丙酸

• 常用名: 丙酸
• 英文名: Ronacaleret
• CAS号: 753449-67-1
• 分子量: 449.53100
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₅H₃₃F₂NO₄
• 熔点: N/A
• 闪点: N/A

丙酸用途

A potent calcium sensing receptor (CaSR) negative allosteric modulator with IC50 of 146 nM for hCaSR.

丙酸名称

• 中文名: 丙酸
• 英文名: (2R)-1-(2,3-difluorophenoxy)-3-[[1-(2,3-dihydro-1H-inden-2-yl)-2-methylpropan-2-yl]amino]propan-2-ol,propanoic acid

丙酸物理化学性质

• 分子式: C₂₅H₃₃F₂NO₄
• 分子量: 449.53100
• 精确质量: 449.23800
• PSA: 78.79000
• LogP: 4.74970
• InChIKey: FQJISUPNMFRIFZ-HXUWFJFHSA-N
• SMILES: CC(C)(CC1Cc2ccccc2C1)NCC(O)COc1cc(CCC(=O)O)cc(F)c1F

丙酸靶点实验

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实验名称：Lipophilicity, log D of the compound 来源：ChEMBL 靶标：N/A External Id：CHEMBL1785983

实验名称：Increase in PTH (1-84) release response in Sprague-Dawley rat at 10 mg/kg, po by PTH ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1785637

实验名称：Oral bioavailability in Sprague-Dawley rat at 10 mg/kg 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL1785639

实验名称：Human CaS receptor (Calcium-sensing receptor) 来源：IUPHAR-DB 靶标：CaS receptor (Calcium-sensing receptor) [Homo sapiens] External Id：54_Human

实验名称：Inhibition of human ERG at 10 uM by whole cell voltage clamp technique 来源：ChEMBL 靶标：Potassium voltage-gated channel subfamily H member 2 External Id：CHEMBL1785980

实验名称：Negative allosteric modulator activity at human recombinant calcium sensing receptor ... 来源：ChEMBL 靶标：Extracellular calcium-sensing receptor External Id：CHEMBL1785979

实验名称：Intrinsic clearance in rat liver microsomes assessed per mg of protein 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1785982

实验名称：Intrinsic clearance in human liver microsomes assessed per mg of protein 来源：ChEMBL 靶标：Liver microsomes External Id：CHEMBL1785981

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