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Rimcazole

更新时间:2025-08-24 07:11:30

Rimcazole结构式
Rimcazole结构式
品牌特惠专场
常用名 Rimcazole 英文名 Rimcazole
CAS号 75859-04-0 分子量 321.45900
密度 1.14g/cm3 沸点 499.1ºC at 760 mmHg
分子式 C21H27N3 熔点 N/A
MSDS N/A 闪点 255.7ºC

 Rimcazole用途


Rimcazole (BW 234U) 是一种有效的抗精神病试剂。Rimcazole 也是sigma 位点的竞争性拮抗剂。Rimcazole 可用于急性精神分裂症疾病的研究。

 Rimcazole名称

英文名 9-{3-[(3R,5S)-3,5-Dimethyl-1-piperazinyl]propyl}-9H-carbazole
英文别名 更多

 Rimcazole生物活性

描述 Rimcazole (BW 234U) 是一种有效的抗精神病试剂。Rimcazole 也是sigma 位点的竞争性拮抗剂。Rimcazole 可用于急性精神分裂症疾病的研究。
相关类别
参考文献

[1]. R.M. Ferris, et al. Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain, Life Sciences,Volume 38, Issue 25, 1986, Pages 2329-2337, ISSN 0024-3205.

 Rimcazole物理化学性质

密度 1.14g/cm3
沸点 499.1ºC at 760 mmHg
分子式 C21H27N3
分子量 321.45900
闪点 255.7ºC
精确质量 321.22000
PSA 20.20000
LogP 4.13350
InChIKey GUDVQJXODNJRIJ-CALCHBBNSA-N
SMILES CC1CN(CCCn2c3ccccc3c3ccccc32)CC(C)N1
折射率 1.627

 Rimcazole合成线路

~73%

Rimcazole结构式

Rimcazole

75859-04-0

文献:Naito, Hiroyuki; Hata, Takeshi; Urabe, Hirokazu Organic Letters, 2010 , vol. 12, # 6 p. 1228 - 1230

~%

Rimcazole结构式

Rimcazole

75859-04-0

文献:UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE Patent: WO2008/40950 A1, 2008 ; Location in patent: Page/Page column 13-15 ;

 Rimcazole靶点实验

查看更多实验

实验名称:Binding affinity of Sigma opioid receptor type 1 in Guinea pig brain membranes using ...
来源:ChEMBL
靶标:N/A
External Id:CHEMBL805014
实验名称:Inhibition of Dopamine uptake in male Sprague-Dawley rats using [3H]DA ligand
来源:ChEMBL
靶标:Sodium-dependent dopamine transporter
External Id:CHEMBL675223
实验名称:Inhibition of human SRB1-mediated Hepatitis C virus genotype 2a entry into human 293T...
来源:ChEMBL
靶标:Scavenger receptor class B member 1
External Id:CHEMBL1918056
实验名称:Selectivity ratio for DAT to SERT evaluated
来源:ChEMBL
靶标:Monoamine transporters; serotonin & dopamine
External Id:CHEMBL848169
实验名称:Selectivity ratio of DAT to that of NET receptor
来源:ChEMBL
靶标:Monoamine transporters; Norepinephrine & dopamine
External Id:CHEMBL846369
实验名称:Binding affinity was evaluated using [3H]-DTG binding to sigma-2 receptor from rat li...
来源:ChEMBL
靶标:N/A
External Id:CHEMBL808905
实验名称:Displacement of [3H]-pentazocine from sigma 1 receptor in guinea pig brain cortical m...
来源:ChEMBL
靶标:Sigma non-opioid intracellular receptor 1
External Id:CHEMBL3877494
实验名称:Binding affinity for serotonin 5-hydroxytryptamine 2 receptor using [3H]ketanserin in...
来源:ChEMBL
靶标:5-hydroxytryptamine receptor 2C
External Id:CHEMBL617147
实验名称:Binding affinity for dopamine D2 receptor using [3H]spiperone in guinea pig striatum
来源:ChEMBL
靶标:D(2) dopamine receptor
External Id:CHEMBL673013
实验名称:S16 Schwann cell viability assay (CellTiter-Glo assay)
来源:NCGC
靶标:N/A
External Id:cmt-p4-fda-celltiter_regid
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 Rimcazole英文别名

9-{3-[(3R,5S)-3,5-dimethylpiperazin-1-yl]propyl}-9H-carbazole
BIS(CYCLOPENTADIENYL)ZIRCONIUM BIS(TRI-F LUOROMETHANESULFONATE),THF ADD
ZIRCONOCENE BIS(TRIFLATE)TETRAHYDROFURAN ADDUCT
Zirconocene Bis(trifluoromethanesulfonate)
9-[3-(3,5-cis-dimethylpiperazino)propyl]-carbazole
bis(cyclopentadienyl)zirconium bis(trifluoromethanesulfonate)
cis-9-[3-(3,5-dimethyl-1-piperazinyl)propyl]-9H-carbazole
Cp2Zr(OTf)2oTHF
CpCr(CO)2Cl
Zirconocene bis(triflate) tetrahydrofuran Adduct (C5H5)2Zr(OSO2CF3)2
bis(cyclopentadienyl)zirconium(iv) bis(trifluoromethanesulfonate) thf complex
zirconocene bis(trifluoromethanesul-fonate) thf complex
Di(cyclopentadienyl)zirconium(IV)
ZIRCONOCENE BIS(TRIFLUOROMETHANESULFONATE)TETRAHYDROFURAN ADDUCT
zirconocene bis(triflate)
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