4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide

• 常用名: 4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide
• 英文名: 4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide
• CAS号: 769960-39-6
• 分子量: 508.0
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₆ClN₅O₄
• 熔点: N/A
• 闪点: N/A

名称

• 英文名: 4-({2-[(4-chloro-3-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}phenyl)amino]-1,3-benzoxazol-5-yl}oxy)-N-methylpyridine-2-carboxamide

物理化学性质

• 分子式: C₂₆H₂₆ClN₅O₄
• 分子量: 508.0
• InChIKey: KMNCFOUKJYOZIF-KRWDZBQOSA-N
• SMILES: CNC(=O)c1cc(Oc2ccc3oc(Nc4ccc(Cl)c(OCC5CCCN5C)c4)nc3c2)ccn1

靶点实验

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实验名称：Selectivity for KDR over Tie2 kinase 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2) External Id：CHEMBL894843

实验名称：Selectivity for KDR over FGFR 来源：ChEMBL 靶标：N/A External Id：CHEMBL894844

实验名称：Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL895902

实验名称：Selectivity for KDR over GSK3b 来源：ChEMBL 靶标：N/A External Id：CHEMBL895934

实验名称：HTRF Kinase Inhibition Assay from Article 10.1021/jm070034i: "Design, Synthesis, and ... 来源：BindingDB 靶标：N/A External Id：BindingDB_2165_1

实验名称：Half life in Sprague-Dawley rat at 1 mg/kg, iv or 10 mg/kg po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL895903

实验名称：Selectivity for KDR over CDK 来源：ChEMBL 靶标：N/A External Id：CHEMBL895935

实验名称：Selectivity for KDR over cFMS kinase 来源：ChEMBL 靶标：N/A External Id：CHEMBL895936

实验名称：Oral bioavailability in Sprague-Dawley rat at 3 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL895905

实验名称：Selectivity for KDR over cKit kinase 来源：ChEMBL 靶标：VEGF-receptor 2 and stem cell growth factor receptor (KDR and KIT) External Id：CHEMBL895937

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