Abarelix acetate

• 常用名: Abarelix acetate
• 英文名: Abarelix acetate
• CAS号: 785804-17-3
• 分子量: 1476.115
• 密度: N/A
• 沸点: N/A
• 分子式: C₇₄H₉₉ClN₁₄O₁₆
• 熔点: N/A
• 闪点: N/A

Abarelix acetate用途

Abarelix acetate is a synthetic third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It increases histamine release from rat peritoneal mast cells in vitro and from a human skin model ex vivo. In vivo, abarelix decreases plasma luteinizing hormone (LH) levels six hours post-treatment in castrated rats, with levels returning to baseline within 24 hours.3 Abarelix (2 mg/kg) also transiently decreases plasma testosterone levels in intact rats, with levels returning to baseline within seven days post-treatment. Formulations containing abarelix have previously been used in the treatment of advanced prostate cancer.

Abarelix acetate名称

• 英文名: Abarelix (acetate)

Abarelix acetate物理化学性质

• 分子式: C₇₄H₉₉ClN₁₄O₁₆
• 分子量: 1476.115
• 精确质量: 1474.705200
• InChIKey: ZRHCGBCCWJPSQF-JOOIWXSYSA-N
• SMILES: CC(=O)NC(Cc1ccc2ccccc2c1)C(=O)NC(Cc1ccc(Cl)cc1)C(=O)NC(Cc1cccnc1)C(=O)NC(CO)C(=O)N(C)C(Cc1ccc(O)cc1)C(=O)NC(CC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCCNC(C)C)C(=O)N1CCCC1C(=O)NC(C)C(N)=O.CC(=O)O

Abarelix acetate英文别名

• Abarelix (acetate)
• D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-D-asparaginyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-, acetate ( 1:1)
• MFCD17011970
• N-Acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-D-asparaginyl-L-leucyl-N6-isopropyl-L-lysyl-L-prolyl-D-alaninamide acetate (1:1)