DB818

• 常用名: DB818
• 英文名: DB818
• CAS号: 790241-43-9
• 分子量: 360.439
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₉H₁₆N₆S
• 熔点: N/A
• 闪点: N/A

DB818用途

DB818(DB-818,DB 818)是HOXA9/DNA相互作用的小分子抑制剂,通过作为HOXA9同源序列上的小沟DNA配体结合；直接结合HOXA9同源序列,Kd值为4.6 nM(HBS序列)；改变HOXA9介导的转录,细胞存活和细胞周期在HOXA9介导的表达HOXA9的鼠MigA9细胞中线。

DB818名称

• 英文名: DB818

DB818生物活性

• 描述: DB818(DB-818,DB 818)是HOXA9/DNA相互作用的小分子抑制剂,通过作为HOXA9同源序列上的小沟DNA配体结合；直接结合HOXA9同源序列,Kd值为4.6 nM(HBS序列)；改变HOXA9介导的转录,细胞存活和细胞周期在HOXA9介导的表达HOXA9的鼠MigA9细胞中线。
• 参考文献: References 1. Depauw S, et al. J Med Chem. 2019 Jan 15. doi: 10.1021/acs.jmedchem.8b01448. View Related Products by Target Other Targets

DB818物理化学性质

• 分子式: C₁₉H₁₆N₆S
• 分子量: 360.439
• InChIKey: MSQVFIHMHRAMOC-UHFFFAOYSA-N
• SMILES: N=C(N)c1ccc(-c2ccc(-c3nc4ccc(C(=N)N)cc4[nH]3)s2)cc1

DB818靶点实验

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实验名称：Induction of arfgef1 mRNA expression in mouse MigA9 cells at 5 to 10 uM incubated for... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814241

实验名称：Induction of integrin alpha M mRNA expression in mouse MigA9 cells at 5 to 10 uM incu... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814242

实验名称：Induction of Akap13 mRNA expression in mouse MigA9 cells at 5 to 10 uM incubated for ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814239

实验名称：Induction of oasl2 mRNA expression in mouse MigA9 cells at 5 to 10 uM incubated for 4... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814240

实验名称：Induction of cell cycle arrest in mouse MigA9 cells expressing mouse Hoxa9 assessed a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814245

实验名称：Induction of cell cycle arrest in mouse MigA9 cells expressing mouse Hoxa9 assessed a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814246

实验名称：Inhibition of HOXA9 (unknown origin) expressed in reticulocyte lysate system binding ... 来源：ChEMBL 靶标：HOXA9 DNA binding site External Id：CHEMBL4814243

实验名称：Induction of cell cycle arrest in mouse MigA9 cells expressing mouse Hoxa9 assessed a... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814244

实验名称：Downregulation of pim1 gene in mouse MigA9 cells by ingenuity pathway analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814233

实验名称：Upregulation of rgs10 gene in mouse MigA9 cells by ingenuity pathway analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4814234

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