ML-184

• 常用名: ML-184
• 英文名: ML 184
• CAS号: 794572-10-4
• 分子量: 470.628
• 密度: 1.2±0.1 g/cm3
• 沸点: 681.4±65.0 °C at 760 mmHg
• 分子式: C₂₅H₃₄N₄O₃S
• 熔点: N/A
• 闪点: 365.9±34.3 °C

ML-184用途

ML-184(ML184)是一种有效的选择性GPR55激动剂,对GPR35,CB1和CB2的EC50为263nM,>120倍,83倍和57倍；显示激活ERK磷酸化下游反应的活性和PKCβII易位。

ML-184名称

• 中文名: ML 184,GPR55激动剂
• 英文名: CID2440433

ML-184生物活性

• 描述: ML-184(ML184)是一种有效的选择性GPR55激动剂,对GPR35,CB1和CB2的EC50为263nM,>120倍,83倍和57倍；显示激活ERK磷酸化下游反应的活性和PKCβII易位。
• 参考文献: References 1. Heynen-Genel S, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. 2. Lingerfelt MA, et al. Biochemistry. 2017 Jan 24;56(3):473-486. View Related Products by Target GPR55

ML-184物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 681.4±65.0 °C at 760 mmHg
• 分子式: C₂₅H₃₄N₄O₃S
• 分子量: 470.628
• 闪点: 365.9±34.3 °C
• 精确质量: 470.235168
• LogP: 2.29
• InChIKey: VRSJAHQGJHDACS-UHFFFAOYSA-N
• SMILES: Cc1cccc(N2CCN(C(=O)c3cc(S(=O)(=O)N(C)C)ccc3N3CCCC3)CC2)c1C
• 蒸汽压: 0.0±2.1 mmHg at 25°C
• 折射率: 1.607
• 储存条件: -20°C

ML-184靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

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ML-184英文别名

• MFCD06367291
• 3-{[4-(2,3-Dimethylphenyl)-1-piperazinyl]carbonyl}-N,N-dimethyl-4-(1-pyrrolidinyl)benzenesulfonamide
• CID2440433