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2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-

更新时间:2024-01-11 17:30:52

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-结构式
2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-结构式
品牌特惠专场
常用名 2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- 英文名 2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-
CAS号 81691-06-7 分子量 258.23
密度 1.576g/cm3 沸点 N/A
分子式 C10H14N2O6 熔点 N/A
MSDS N/A 闪点 N/A

 用途


3-甲基-5-β-D-呋喃核糖基-2,4(1H,3H)-嘧啶二酮是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

 名称

英文名 3-methylpseudouridine

 生物活性

描述 3-甲基-5-β-D-呋喃核糖基-2,4(1H,3H)-嘧啶二酮是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。
相关类别
参考文献

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 物理化学性质

密度 1.576g/cm3
分子式 C10H14N2O6
分子量 258.23
精确质量 258.08500
PSA 124.78000
折射率 1.618

 合成线路

~87%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-结构式

2,4(1H,3H)-Pyri...

81691-06-7

文献:Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-结构式

2,4(1H,3H)-Pyri...

81691-06-7

文献:Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-结构式

2,4(1H,3H)-Pyri...

81691-06-7

文献:Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-结构式

2,4(1H,3H)-Pyri...

81691-06-7

文献:Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-结构式

2,4(1H,3H)-Pyri...

81691-06-7

文献:Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-结构式

2,4(1H,3H)-Pyri...

81691-06-7

文献:Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-结构式

2,4(1H,3H)-Pyri...

81691-06-7

文献:Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-结构式

2,4(1H,3H)-Pyri...

81691-06-7

文献:Matsuda; Pankiewicz; Marcus; Watanabe; Fox Carbohydrate research, 1982 , vol. 100, p. 297 - 302

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-结构式

2,4(1H,3H)-Pyri...

81691-06-7

文献:Matsuda; Pankiewicz; Marcus; Watanabe; Fox Carbohydrate research, 1982 , vol. 100, p. 297 - 302