Ym-244769

• 常用名: Ym-244769
• 英文名: Ym-244769
• CAS号: 838819-70-8
• 分子量: 443.47
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₂FN₃O₃
• 熔点: N/A
• 闪点: N/A

Ym-244769用途

YM-244769是一种有效的NCX(钠/钙交换)抑制剂,优先抑制NCX3,IC50为18 nM。YM-244769可有效防止缺氧/复氧诱导的SH-SY5Y神经细胞损伤[1]。

Ym-244769名称

• 英文名: YM-244769

Ym-244769生物活性

• 描述: YM-244769是一种有效的NCX(钠/钙交换)抑制剂,优先抑制NCX3,IC50为18 nM。YM-244769可有效防止缺氧/复氧诱导的SH-SY5Y神经细胞损伤[1]。
• 相关类别:
  研究领域 >> 神经疾病
• 靶点实验:

  IC50: 18 nM (NCX3)[1]

• 体外研究: YM-244769通过NCX3优先抑制细胞内依赖Na+的45Ca2+摄取；这种抑制作用是通过NCX1或NCX2摄取的3.8到5.3倍【1】。
• 参考文献:

  [1]. Iwamoto T, Kita S. YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol Pharmacol. 2006 Dec;70(6):2075-83.

Ym-244769物理化学性质

• 分子式: C₂₆H₂₂FN₃O₃
• 分子量: 443.47
• InChIKey: JZMLHJRKSJXARY-UHFFFAOYSA-N
• SMILES: Nc1cccc(CNC(=O)c2ccc(Oc3ccc(OCc4cccc(F)c4)cc3)nc2)c1

Ym-244769靶点实验

查看更多实验

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