[6-甲氧基-2-(4-甲氧基苯基)-苯并[b]噻吩-3-基] {4-[2-(1-哌啶基)乙氧基]苯基}甲酮盐酸盐

• 常用名: [6-甲氧基-2-(4-甲氧基苯基)-苯并[b]噻吩-3-基] {4-[2-(1-哌啶基)乙氧基]苯基}甲酮盐酸盐
• 英文名: Raloxifene Bismethyl Ether hydrochloride
• CAS号: 84541-36-6
• 分子量: 538.09700
• 密度: N/A
• 沸点: N/A
• 分子式: C₃₀H₃₂ClNO₄S
• 熔点: N/A
• 闪点: N/A

用途

Raloxifene Bismethyl Ether hydrochloride 是一种 Raloxifene 的代谢产物,并且是两个羟基都不存在的雌激素受体非活性化合物。

名称

• 中文名: [6-羟基-2-(4-羟基苯基)-苯并噻吩-3-基]-[4-[2-(1-哌啶)乙氧基]苯基]-甲酮
• 英文名: [6-Methoxy-2-(4-methoxyphenyl)-1-benzothiophen-3-yl]{4-[2-(1-pipe ridinyl)ethoxy]phenyl}methanone hydrochloride (1:1)

生物活性

• 描述: Raloxifene Bismethyl Ether hydrochloride 是一种 Raloxifene 的代谢产物,并且是两个羟基都不存在的雌激素受体非活性化合物。
• 相关类别:
  研究领域 >> 其他
  信号通路 >> 其他 >> 其他
• 体外研究: 雷洛昔芬双甲醚对离体梁模型的组织韧性没有影响[1]。
• 参考文献:

  [1]. Gallant MA, et al. Bone cell-independent benefits of raloxifene on the skeleton: a novel mechanism for improving bone material properties. Bone. 2014 Apr;61:191-200.

物理化学性质

• 分子式: C₃₀H₃₂ClNO₄S
• 分子量: 538.09700
• 精确质量: 537.17400
• PSA: 76.24000
• LogP: 7.42110
• InChIKey: MPPNHHUKVJDWQV-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2sc3cc(OC)ccc3c2C(=O)c2ccc(OCCN3CCCCC3)cc2)cc1.Cl

靶点实验

查看更多实验

实验名称：In vitro relative binding affinity by competition with [3H]17-beta-estradiol for estr... 来源：ChEMBL 靶标：Estrogen receptor beta External Id：CHEMBL682115

实验名称：Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition... 来源：ChEMBL 靶标：Estrogen receptor beta External Id：CHEMBL708494

实验名称：Percent decrease in serum cholesterol relative to OVX control at 10 mg/kg in rat was ... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL780177

实验名称：Minimum effective dose at which significant increase in uterine eosinophil peroxidase... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL785547

实验名称：Minimum effective dose at which significant increase in uterine weight/body weight in... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL787611

实验名称：Minimum effective dose at which significant increase in uterine weight/body weight in... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL785548

实验名称：Percent decrease in serum cholesterol relative to OVX control at 0.1 mg/kg in rat was... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL780172

实验名称：Dose required to reduce serum cholesterol by 50% relative to OVX controls was determi... 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL776448

实验名称：Percent decrease in serum cholesterol relative to OVX control at 1 mg/kg in rat 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL780174

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英文别名

• 6-methoxy-2-(4-methoxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]benzo[b]thiophene
• 6-methoxy-2-(4-methoxyphenyl)-3-[4-(2-piperidinylethoxy)benzoyl]benzo[b]thiophene
• 1-(2-{4-[6-methoxy-2-(4-methoxyphenyl)-benzo-[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidinium chloride
• 6-Methoxy-2-(4-methoxyphenyl)-3-[4-(2-piperidinylethoxy)benzoyl]-benzo[b]thiophene Hydrochloride
• (4-(2-(piperidin-1-yl)ethoxy)phenyl)(6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophen-3-yl)methanone
• 1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidine
• <6-methoxy-2-(4-methoxyphenyl)benzo<b>thien-3-yl><4-<2-(1-piperidinyl)ethoxy>phenyl>methanone hydrochloride
• [6-Methoxy-2-(4-Methoxyphenyl)benzo[b]thien-3-yl]-[4-[2-(1-Piperidinyl)ethoxy]phenyl] Methanone
• Raloxifene Bismethyl Ether
• [6-methoxy-2-(4-methoxyphenyl)benzo[b]thiophene][4-(2-(piperidin-1-yl)ethoxy)phenyl]methanone
• 6-Methoxy-2-(4-methoxyphenyl)-3-[4-(2-piperidinoethoxy)benzoyl]-benzo[b]thiophene Hydrochloride
• 1-(2-{4-[6-Methoxy-2-(4-methoxy-phenyl)-benzo[b]thiophene-3-carbonyl]-phenoxy}-ethyl)-piperidin
• [2-(4-methoxyphenyl)-6-methoxybenzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride