N-(3-氰基噻吩-2-基)吡啶-2-甲酰胺

• 常用名: N-(3-氰基噻吩-2-基)吡啶-2-甲酰胺
• 英文名: Casein kinase 1δ-IN-1
• CAS号: 851871-94-8
• 分子量: 229.26
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₁H₇N₃OS
• 熔点: N/A
• 闪点: N/A

N-(3-氰基噻吩-2-基)吡啶-2-甲酰胺用途

酪蛋白激酶1δ-IN-1(化合物822)是酪蛋白激酶1delta(CK1δ)的抑制剂,抑制率大于5%。酪蛋白激酶1δ-IN-1可用于神经退行性疾病,如阿尔茨海默病研究[1]。

N-(3-氰基噻吩-2-基)吡啶-2-甲酰胺名称

• 中文名: N-(3-氰基噻吩-2-基)吡啶-2-甲酰胺
• 英文名: N-(3-Cyanothiophen-2-yl)picolinamide

N-(3-氰基噻吩-2-基)吡啶-2-甲酰胺生物活性

• 描述: 酪蛋白激酶1δ-IN-1(化合物822)是酪蛋白激酶1delta(CK1δ)的抑制剂,抑制率大于5%。酪蛋白激酶1δ-IN-1可用于神经退行性疾病,如阿尔茨海默病研究[1]。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> 酪蛋白激酶
  研究领域 >> 神经疾病
  信号通路 >> 干细胞及 Wnt 通路 >> 酪蛋白激酶
• 靶点实验:

  CKIδ

• 参考文献:

  [1]. Sheridan Joseph M, et al. Casein kinase 1δ inhibitors for the treatment of neurodegenerative disorders: World Intellectual Property Organization, WO2012080729[P]. 2012-06-21.

N-(3-氰基噻吩-2-基)吡啶-2-甲酰胺物理化学性质

• 分子式: C₁₁H₇N₃OS
• 分子量: 229.26
• InChIKey: XNEHUAKGYXQSBF-UHFFFAOYSA-N
• SMILES: N#Cc1ccsc1NC(=O)c1ccccn1
• 储存条件: 2-8°C， 干燥

N-(3-氰基噻吩-2-基)吡啶-2-甲酰胺靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Inhibition of beta lactamase CTX-M assessed as hydrolysis of beta lactam up to 5 mM b... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1220444

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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N-(3-氰基噻吩-2-基)吡啶-2-甲酰胺英文别名

• MFCD06387193