PF-915275

• 常用名: PF-915275
• 英文名: PF 915275
• CAS号: 857290-04-1
• 分子量: 350.394
• 密度: 1.4±0.1 g/cm3
• 沸点: 610.9±65.0 °C at 760 mmHg
• 分子式: C₁₈H₁₄N₄O₂S
• 熔点: N/A
• 闪点: 323.3±34.3 °C

PF-915275用途

PF-915275是一种有效的选择性人11β-羟基类固醇脱氢酶1型 (11βHSD1) 抑制剂 (Ki ＜ 1 nM), 具有良好的临床前药物代谢动力学性质。

PF-915275名称

• 中文名: PF-915275
• 英文名: N-(6-aminopyridin-2-yl)-4-(4-cyanophenyl)benzenesulfonamide

PF-915275生物活性

• 描述: PF-915275是一种有效的选择性人11β-羟基类固醇脱氢酶1型 (11βHSD1) 抑制剂 (Ki ＜ 1 nM), 具有良好的临床前药物代谢动力学性质。
• 相关类别:
  信号通路 >> 其他 >> 其他
  研究领域 >> 代谢疾病
• 参考文献:

  [1]. Bhat BG, et al. Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolg

  [2]. Siu M, et al. N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3493-7.

PF-915275物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 610.9±65.0 °C at 760 mmHg
• 分子式: C₁₈H₁₄N₄O₂S
• 分子量: 350.394
• 闪点: 323.3±34.3 °C
• 精确质量: 350.083740
• PSA: 117.25000
• LogP: 2.06
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.709
• 储存条件: 2-8℃

PF-915275靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：Inhibition of N-terminal MKHQHQHQHQHQHQQPL-tagged 11beta-HSD1 C272S mutant (unknown o... 来源：ChEMBL 靶标：11-beta-hydroxysteroid dehydrogenase 1 External Id：CHEMBL4312828

实验名称：Inhibition of human 11beta-HSD2 in HEK293 cells at 10 uM 来源：ChEMBL 靶标：11-beta-hydroxysteroid dehydrogenase type 2 External Id：CHEMBL997252

实验名称：Bioavailability in rat at 0.1 mg/kg, iv and 1 mg/kg, po 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL998075

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t... 来源：NCGC 靶标：N/A External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit... 来源：NCGC External Id：CIB1-p1-p2

实验名称：Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screeni... 来源：NCGC 靶标：N/A External Id：CPF001

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PF-915275英文别名

• N-(6-Amino-2-pyridinyl)-4'-cyano-4-biphenylsulfonamide
• 4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide
• N-(6-aminopyridin-2-yl)-4'-cyanobiphenyl-4-sulfonamide
• PF-915275